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AACS sirna

Scan QR to view Datasheet Catalog #    MBS827474 AACS sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   

AACS siRNA (Mouse)

 Product Synonym Names    Acetoacetyl-CoA synthetase
 Product Gene Name   

AACS sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9D2R0
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    AACS siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse AACS gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of AACS sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AACS sirna

   siRNA to inhibit AACS expression using RNA interference
 Applications Tested/Suitable for AACS sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for AACS. It may not necessarily be applicable to this product.
 NCBI GI #    21313520
 NCBI GeneID    78894
 NCBI Accession #    NP_084486.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_030210.1 [Other Products]
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 UniProt Primary Accession #    Q9D2R0 [Other Products]
 UniProt Secondary Accession #    Q3TCL8; Q3UD39; A1IG47 [Other Products]
 UniProt Related Accession #    Q9D2R0 [Other Products]
 Molecular Weight    75,200 Da
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 NCBI Official Full Name    acetoacetyl-CoA synthetase
 NCBI Official Synonym Full Names    acetoacetyl-CoA synthetase
 NCBI Official Symbol    Aacs [Similar Products]
 NCBI Official Synonym Symbols   
SUR5; 2210408B16Rik
[Similar Products]
 NCBI Protein Information    acetoacetyl-CoA synthetase
 UniProt Protein Name    Acetoacetyl-CoA synthetase
 Protein Family    Acetoacetyl-CoA synthetase
 UniProt Gene Name    Aacs [Similar Products]
 UniProt Entry Name    AACS_MOUSE
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 UniProt Comments for AACS    AACS: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development. Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - butanoate; EC; Ligase

Cellular Component: cytoplasm; cytosol

Molecular Function: butyrate-CoA ligase activity; nucleotide binding; catalytic activity; ATP binding; ligase activity; acetoacetate-CoA ligase activity

Biological Process: response to drug; response to oleate; response to ethanol; metabolic process; positive regulation of insulin secretion; lipid metabolic process; liver development; fatty acid metabolic process; response to organic nitrogen; response to organic cyclic substance; response to nutrient
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 Research Articles on AACS    1. Knockdown of AACS inhibits differentiation of 3T3-L1 adipocytes and suppresses expression of the adipocyte markers, peroxisome proliferator-activated receptor gama and CCAAT/enhancer binding protein alpha.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AACS sirnaPathways associated with AACS sirna
 Reference Product  PubMed Publications
 Acly sirna  >1 publications with AACS and Acly
 Products by Pathway  Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Valine, Leucine And Isoleucine Degradation Pathway antibodies  Valine, Leucine And Isoleucine Degradation Pathway Diagram
 Valine, Leucine And Isoleucine Degradation Pathway antibodies  Valine, Leucine And Isoleucine Degradation Pathway Diagram
Diseases associated with AACS sirnaOrgans/Tissues associated with AACS sirna
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >6 publications with AACS and Kidney Diseases
 Atherosclerosis Antibodies  >4 publications with AACS and Atherosclerosis
 Disease Models, Animal Antibodies  >4 publications with AACS and Disease Models, Animal
 Pain Antibodies  >3 publications with AACS and Pain
 Acute Kidney Injury Antibodies  >3 publications with AACS and Acute Kidney Injury
 Edema Antibodies  >2 publications with AACS and Edema
 Inflammation Antibodies  >2 publications with AACS and Inflammation
 Congenital Abnormalities Antibodies  >2 publications with AACS and Congenital Abnormalities
 Fatty Liver Antibodies  >2 publications with AACS and Fatty Liver
 Necrosis Antibodies  >2 publications with AACS and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >19 publications with AACS and Brain
 Blood Antibodies  >15 publications with AACS and Blood
 Bone Antibodies  >10 publications with AACS and Bone
 Kidney Antibodies  >10 publications with AACS and Kidney
 Liver Antibodies  >8 publications with AACS and Liver
 Heart Antibodies  >7 publications with AACS and Heart
 Adipose Tissue Antibodies  >6 publications with AACS and Adipose Tissue
 Skin Antibodies  >4 publications with AACS and Skin
 Connective Tissue Antibodies  >4 publications with AACS and Connective Tissue
 Bone Marrow Antibodies  >1 publications with AACS and Bone Marrow
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