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AAGAB sirna

Scan QR to view Datasheet Catalog #    MBS8215777 AAGAB sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AAGAB, siRNA

★Popular Item★
 Also Known As   

AAGAB siRNA (Human)

 Product Synonym Names    Alpha- and gamma-adaptin-binding protein p34
 Product Gene Name   

AAGAB sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    148600
 3D Structure    ModBase 3D Structure for Q6PD74
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    AAGAB siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human AAGAB gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of AAGAB sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AAGAB sirna

   siRNA to inhibit AAGAB expression using RNA interference
 Applications Tested/Suitable for AAGAB sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for AAGAB. It may not necessarily be applicable to this product.
 NCBI GI #    428978472
 NCBI GeneID    79719
 NCBI Accession #    NP_001258814.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001271885.1 [Other Products]
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 UniProt Primary Accession #    Q6PD74 [Other Products]
 UniProt Secondary Accession #    Q6FI86; Q7Z5X9; Q9H0P1; Q9HAK0; B4DG44 [Other Products]
 UniProt Related Accession #    Q6PD74 [Other Products]
 Molecular Weight    22,719 Da
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 NCBI Official Full Name    alpha- and gamma-adaptin-binding protein p34 isoform 2
 NCBI Official Synonym Full Names    alpha- and gamma-adaptin binding protein
 NCBI Official Symbol    AAGAB [Similar Products]
 NCBI Official Synonym Symbols   
p34; KPPP1; PPKP1; PPKP1A
[Similar Products]
 NCBI Protein Information    alpha- and gamma-adaptin-binding protein p34
 UniProt Protein Name    Alpha- and gamma-adaptin-binding protein p34
 Protein Family    Alpha- and gamma-adaptin-binding protein
 UniProt Gene Name    AAGAB [Similar Products]
 UniProt Entry Name    AAGAB_HUMAN
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 NCBI Summary for AAGAB    The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
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 UniProt Comments for AAGAB    AAGAB: May play a role in membrane traffic.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 15q23

Cellular Component: nucleoplasm; cytoplasm; cytosol

Biological Process: protein transport

Disease: Palmoplantar Keratoderma, Punctate Type Ia
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 Research Articles on AAGAB    1. results reveal one novel and two recurrent mutations in AAGAB providing further evidence of its role in the pathogenesis of palmoplantar keratoderma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with AAGAB sirnaOrgans/Tissues associated with AAGAB sirna
 Disease Name  Pubmed Publications
 Keratoderma, Palmoplantar Antibodies  >13 publications with AAGAB and Keratoderma, Palmoplantar
 Carcinoma Antibodies  >1 publications with AAGAB and Carcinoma
 Inflammation Antibodies  >1 publications with AAGAB and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >4 publications with AAGAB and Skin
 Blood Antibodies  >1 publications with AAGAB and Blood
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