NP_001079.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,432 Da
NCBI Official Full Name
serotonin N-acetyltransferase isoform 2
NCBI Official Synonym Full Names
aralkylamine N-acetyltransferase
NCBI Official Synonym Symbols
NCBI Protein Information
serotonin N-acetyltransferase
UniProt Protein Name
Serotonin N-acetyltransferase
UniProt Synonym Protein Names
Aralkylamine N-acetyltransferase; AA-NAT
UniProt Synonym Gene Names
UniProt Entry Name
SNAT_HUMAN
NCBI Summary for AANAT
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for AANAT
AA-NAT var1: Catalyzes the N-acetylation of serotonin into N- acetylserotonin. Controls the night/day rhythm of melatonin production in the pineal gland. Has a relative affinity for hydroxylated versus non-hydroxylated arylalkylamines. Belongs to the acetyltransferase family. AANAT subfamily. Monomer. Interacts with YWHAZ; the interaction requires phosphorylation on Thr-31, and modulates the enzymatic activity of AANAT through preventing dephosphorylation and/or proteolysis and stabilizing substrate binding. Subsequently, a second molecule of AANAT can bind, via the phosphorylated Ser-205 site, the other YWHAZ monomer with similar effect.
Protein type: EC 2.3.1.87; Acetyltransferase; Amino Acid Metabolism - tryptophan
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: perinuclear region of cytoplasm; cytosol
Molecular Function: arylamine N-acetyltransferase activity; aralkylamine N-acetyltransferase activity
Biological Process: N-terminal protein amino acid acetylation; circadian rhythm; response to light stimulus; melatonin biosynthetic process; response to copper ion; indolalkylamine biosynthetic process; response to zinc ion; response to cytokine stimulus; response to calcium ion; response to corticosterone stimulus; response to insulin stimulus
Disease: Delayed Sleep Phase Syndrome, Susceptibility To
Research Articles on AANAT
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Products associated with AANAT sirna
Pathways associated with AANAT sirna
Diseases associated with AANAT sirna
Organs/Tissues associated with AANAT sirna
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