NP_113948.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
146,258 Da
NCBI Official Full Name
bile salt export pump
NCBI Official Synonym Full Names
ATP-binding cassette, subfamily B (MDR/TAP), member 11
NCBI Official Synonym Symbols
NCBI Protein Information
bile salt export pump
UniProt Protein Name
Bile salt export pump
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 11; Sister of P-glycoprotein
UniProt Synonym Gene Names
UniProt Entry Name
ABCBB_RAT
NCBI Summary for ABCB11
acts as an ATP-dependent bile salt export pump; transports taurochenodeoxycholate, taurocholate, and other bile salts [RGD, Feb 2006]
UniProt Comments for ABCB11
ABCB11: Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis type 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease. Defects in ABCB11 are the cause of benign recurrent intrahepatic cholestasis type 2 (BRIC2). BRIC is characterized by intermittent episodes of cholestasis without progression to liver failure. There is initial elevation of serum bile acids, followed by cholestatic jaundice which generally spontaneously resolves after periods of weeks to months. The cholestatic attacks vary in severity and duration and patients are asymptomatic between episodes, both clinically and biochemically. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Protein type: Transporter, ABC family; Transporter; Membrane protein, integral; Hydrolase; Membrane protein, multi-pass
Cellular Component: Golgi membrane; Golgi apparatus; intercellular canaliculus; membrane; apical part of cell; apical plasma membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; ATPase activity, coupled to transmembrane movement of substances; canalicular bile acid transmembrane transporter activity; drug transporter activity; ATP binding
Biological Process: bile acid and bile salt transport; response to drug; response to estrogen stimulus; metabolic process; canalicular bile acid transport; drug export; multidrug transport; response to oxidative stress; transmembrane transport
Research Articles on ABCB11
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Products associated with ABCB11 sirna
Pathways associated with ABCB11 sirna
Diseases associated with ABCB11 sirna
Organs/Tissues associated with ABCB11 sirna
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