NP_035206.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
140,647 Da
NCBI Official Full Name
multidrug resistance protein 1A
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
NCBI Official Synonym Symbols
Pgp; Mdr3; P-gp; Pgy3; Abcb4; Evi32; Mdr1a; Pgy-3; mdr-3 [Similar Products]
NCBI Protein Information
multidrug resistance protein 1A
UniProt Protein Name
Multidrug resistance protein 1A
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 1A; MDR1A; Multidrug resistance protein 3; P-glycoprotein 3
UniProt Synonym Gene Names
UniProt Entry Name
MDR1A_MOUSE
NCBI Summary for ABCB1A
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCB1A
ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.
Protein type: Membrane protein, integral; Transporter, ABC family; EC 3.6.3.44; Hydrolase; Cell adhesion; Membrane protein, multi-pass; Transporter
Cellular Component: intercellular canaliculus; cell surface; membrane; apical part of cell; plasma membrane; integral to membrane
Molecular Function: hydrolase activity; ATPase activity, coupled to transmembrane movement of substances; ATPase activity; nucleotide binding; ATPase activity, coupled; xenobiotic-transporting ATPase activity; ATP binding
Biological Process: daunorubicin transport; hormone transport; drug transport; transport; drug export; xenobiotic transport; multidrug transport; G2/M transition of mitotic cell cycle; transmembrane transport
Research Articles on ABCB1A
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Products associated with ABCB1A sirna
Pathways associated with ABCB1A sirna
Diseases associated with ABCB1A sirna
Organs/Tissues associated with ABCB1A sirna
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