NP_997683.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
82,558 Da
NCBI Official Full Name
ATP-binding cassette sub-family B member 7, mitochondrial
NCBI Official Synonym Full Names
ATP-binding cassette, subfamily B (MDR/TAP), member 7
NCBI Protein Information
ATP-binding cassette sub-family B member 7, mitochondrial
UniProt Protein Name
ATP-binding cassette sub-family B member 7, mitochondrial
UniProt Synonym Protein Names
ATP-binding cassette transporter 7; ABC transporter 7 protein
UniProt Synonym Gene Names
UniProt Entry Name
ABCB7_RAT
NCBI Summary for ABCB7
mouse homolog plays a role in heme biosynthesis in erythroid cells; regulates expression of both the mitochondrial iron-sulfur-containing protein ferrochelatase and the cytosolic iron-sulfur containing protein thioredoxin [RGD, Feb 2006]
UniProt Comments for ABCB7
ABCB7: Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT). ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis. Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Transporter, ABC family; Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass
Cellular Component: mitochondrion; cell; mitochondrial inner membrane; integral to membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP binding
Biological Process: cellular iron ion homeostasis; metabolic process; transmembrane transport
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Products associated with ABCB7 sirna
Pathways associated with ABCB7 sirna
Diseases associated with ABCB7 sirna
Organs/Tissues associated with ABCB7 sirna
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