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ABCC8 sirna

Scan QR to view Datasheet Catalog #    MBS8205897 ABCC8 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCC8, siRNA

 Also Known As   

ABCC8 siRNA (Human)

 Product Synonym Names    HRINS; SUR; SUR1; ATP-binding cassette sub-family C member 8; Sulfonylurea receptor 1
 Product Gene Name   

ABCC8 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    240800
 3D Structure    ModBase 3D Structure for Q09428
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    ABCC8 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human ABCC8 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of ABCC8 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ABCC8 sirna

   siRNA to inhibit ABCC8 expression using RNA interference
 Applications Tested/Suitable for ABCC8 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ABCC8. It may not necessarily be applicable to this product.
 NCBI GI #    118582255
 NCBI GeneID    6833
 NCBI Accession #    NP_000343.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000352.4 [Other Products]
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 UniProt Primary Accession #    Q09428 [Other Products]
 UniProt Secondary Accession #    O75948; Q16583; A6NMX8; E3UYX6 [Other Products]
 UniProt Related Accession #    Q09428 [Other Products]
 Molecular Weight    5,468 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family C member 8 isoform 2
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family C (CFTR/MRP), member 8
 NCBI Official Symbol    ABCC8 [Similar Products]
 NCBI Official Synonym Symbols   
HI; SUR; HHF1; MRP8; PHHI; SUR1; ABC36; HRINS; TNDM2; SUR1delta2
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family C member 8
 UniProt Protein Name    ATP-binding cassette sub-family C member 8
 UniProt Synonym Protein Names   
Sulfonylurea receptor 1
 Protein Family    ABC transporter C family
 UniProt Gene Name    ABCC8 [Similar Products]
 UniProt Synonym Gene Names    HRINS; SUR; SUR1 [Similar Products]
 UniProt Entry Name    ABCC8_HUMAN
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 NCBI Summary for ABCC8    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
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 UniProt Comments for ABCC8    ABCC8: a multi-pass membrane protein subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. Associates with Kir6.2. Defects in ABCC8 are a cause of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) [MIM:601820, 256450], and may contribute to non-insulin-dependent diabetes mellitus (NIDDM) in Northern European Caucasians. Two alternatively spliced human isoforms have been described.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family; Transporter

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: voltage-gated potassium channel complex; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; sulfonylurea receptor activity; potassium ion transmembrane transporter activity; ATP binding

Biological Process: synaptic transmission; carbohydrate metabolic process; energy reserve metabolic process; signal transduction; transmembrane transport; regulation of insulin secretion; potassium ion transport

Disease: Hyperinsulinemic Hypoglycemia, Familial, 1; Diabetes Mellitus, Transient Neonatal, 2; Diabetes Mellitus, Permanent Neonatal; Hypoglycemia, Leucine-induced; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on ABCC8    1. Paternally inherited heterozygous ABCC8/KCNJ11 mutations can manifest as a wide spectrum of congenital hyperinsulinism.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ABCC8 sirnaPathways associated with ABCC8 sirna
 Reference Product  PubMed Publications
 KCNJ11 sirna  >266 publications with ABCC8 and KCNJ11
 INS sirna  >52 publications with ABCC8 and INS
 KCNJ8 sirna  >7 publications with ABCC8 and KCNJ8
 FOXA2 sirna  >2 publications with ABCC8 and FOXA2
 RAPGEF3 sirna  >1 publications with ABCC8 and RAPGEF3
 RAPGEF4 sirna  >1 publications with ABCC8 and RAPGEF4
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ATP Sensitive Potassium Channels Pathway antibodies  ATP Sensitive Potassium Channels Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
Diseases associated with ABCC8 sirnaOrgans/Tissues associated with ABCC8 sirna
 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >251 publications with ABCC8 and Diabetes Mellitus
 Congenital Hyperinsulinism Antibodies  >155 publications with ABCC8 and Congenital Hyperinsulinism
 Diabetes Mellitus, Type 2 Antibodies  >97 publications with ABCC8 and Diabetes Mellitus, Type 2
 Hyperglycemia Antibodies  >48 publications with ABCC8 and Hyperglycemia
 Cardiovascular Diseases Antibodies  >44 publications with ABCC8 and Cardiovascular Diseases
 Diabetes Mellitus, Type 1 Antibodies  >44 publications with ABCC8 and Diabetes Mellitus, Type 1
 Diabetes Mellitus, Transient Neonatal, 2 Antibodies  >27 publications with ABCC8 and Diabetes Mellitus, Transient Neonatal, 2
 Edema Antibodies  >17 publications with ABCC8 and Edema
 Hyperplasia Antibodies  >14 publications with ABCC8 and Hyperplasia
 Seizures Antibodies  >14 publications with ABCC8 and Seizures
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >225 publications with ABCC8 and Pancreas
 Muscle Antibodies  >86 publications with ABCC8 and Muscle
 Brain Antibodies  >83 publications with ABCC8 and Brain
 Heart Antibodies  >66 publications with ABCC8 and Heart
 Bone Antibodies  >6 publications with ABCC8 and Bone
 Eye Antibodies  >2 publications with ABCC8 and Eye
 Lung Antibodies  >2 publications with ABCC8 and Lung
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