NP_001192110.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
38,861 Da
NCBI Official Full Name
abhydrolase domain-containing protein 4 isoform 2
NCBI Official Synonym Full Names
abhydrolase domain containing 4
NCBI Protein Information
abhydrolase domain-containing protein 4
UniProt Protein Name
Abhydrolase domain-containing protein 4
UniProt Synonym Protein Names
Alpha/beta-hydrolase 4; Lyso-N-acylphosphatidylethanolamine lipase
UniProt Entry Name
ABHD4_MOUSE
UniProt Comments for ABHD4
ABHD4: Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine. Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.
Protein type: EC 3.1.1.-; Hydrolase
Molecular Function: retinyl-palmitate esterase activity; sulfolactone hydrolase activity; 3,4-dihydrocoumarin hydrolase activity; hydrolase activity; lipase activity; butyrolactone hydrolase activity; all-trans-retinyl-palmitate hydrolase activity; phospholipase activity; 1-oxa-2-oxocycloheptane lactonase activity; prenylcysteine methylesterase activity
Biological Process: lipid metabolic process; lipid catabolic process
Research Articles on ABHD4
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Organs/Tissues associated with ABHD4 sirna
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