NP_579938.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
acetyl-CoA carboxylase 1
NCBI Official Synonym Full Names
acetyl-Coenzyme A carboxylase alpha
NCBI Official Synonym Symbols
Acac; Acc1; Gm738; A530025K05Rik [Similar Products]
NCBI Protein Information
acetyl-CoA carboxylase 1
UniProt Protein Name
Acetyl-CoA carboxylase 1
UniProt Synonym Protein Names
ACC-alpha; Acetyl-CoA carboxylase 265Including the following 1 domains:Biotin carboxylase (EC:6.3.4.14
UniProt Synonym Gene Names
UniProt Entry Name
ACACA_MOUSE
UniProt Comments for ACACA
ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.
Protein type: Lipid Metabolism - fatty acid biosynthesis; EC 6.4.1.2; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; Ligase; Carbohydrate Metabolism - propanoate
Cellular Component: mitochondrion; cytoplasm; nucleolus; cytosol; actin cytoskeleton
Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; nucleotide binding; biotin carboxylase activity; catalytic activity; kinase binding; biotin binding; ATP binding; ligase activity
Biological Process: acetyl-CoA metabolic process; metabolic process; multicellular organismal protein metabolic process; tissue homeostasis; lipid homeostasis; lipid metabolic process; fatty acid metabolic process; response to organic cyclic substance; fatty acid biosynthetic process; protein homotetramerization
Research Articles on ACACA
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Products associated with ACACA sirna
Pathways associated with ACACA sirna
Diseases associated with ACACA sirna
Organs/Tissues associated with ACACA sirna
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