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ACTC1 sirna

Scan QR to view Datasheet Catalog #    MBS827813 ACTC1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTC1, siRNA

 Also Known As   

ACTC1 siRNA (Mouse)

 Product Synonym Names    ACTC; Actin alpha cardiac muscle 1; Alpha-cardiac actin
 Product Gene Name   

ACTC1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P68033
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    ACTC1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse ACTC1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of ACTC1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ACTC1 sirna

   siRNA to inhibit ACTC1 expression using RNA interference
 Applications Tested/Suitable for ACTC1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ACTC1. It may not necessarily be applicable to this product.
 NCBI GI #    14192922
 NCBI GeneID    11464
 NCBI Accession #    NP_033738.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_009608.4 [Other Products]
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 UniProt Primary Accession #    P68033 [Other Products]
 UniProt Secondary Accession #    P04270 [Other Products]
 UniProt Related Accession #    P68033 [Other Products]
 Molecular Weight    42,019 Da
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 NCBI Official Full Name    actin, alpha cardiac muscle 1
 NCBI Official Synonym Full Names    actin, alpha, cardiac muscle 1
 NCBI Official Symbol    Actc1 [Similar Products]
 NCBI Official Synonym Symbols   
Actc-1
[Similar Products]
 NCBI Protein Information    actin, alpha cardiac muscle 1
 UniProt Protein Name    Actin, alpha cardiac muscle 1
 UniProt Synonym Protein Names   
Alpha-cardiac actin
 Protein Family    Actin
 UniProt Gene Name    Actc1 [Similar Products]
 UniProt Synonym Gene Names    Actc [Similar Products]
 UniProt Entry Name    ACTC_MOUSE
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 UniProt Comments for ACTC1    ACTC1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family.

Protein type: Motility/polarity/chemotaxis; Contractile; Cytoskeletal; Cell development/differentiation; Myosin-binding

Cellular Component: I band; extracellular space; sarcomere; focal adhesion; cytoskeleton; membrane; cytoplasm; actin filament

Molecular Function: myosin binding; ATPase activity; nucleotide binding; ATP binding

Biological Process: actin filament-based movement; metabolic process; muscle thin filament assembly; heart contraction; actomyosin structure organization and biogenesis; cardiac muscle morphogensis; actin-myosin filament sliding; cardiac myofibril assembly; cardiac muscle contraction; negative regulation of apoptosis
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 Research Articles on ACTC1    1. results demonstrate that in ACTC(Co)/KO myofibres, the presence of cardiac alpha-actin instead of skeletal muscle alpha-actin alters actin conformational changes upon activation; this later finely modulates the strain of individual actomyosin interactions and overall lowers myofibre force production
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACTC1 sirnaPathways associated with ACTC1 sirna
 Reference Product  PubMed Publications
 Tnnt2 sirna  >19 publications with ACTC1 and Tnnt2
 Myh7 sirna  >16 publications with ACTC1 and Myh7
 Tnni3 sirna  >12 publications with ACTC1 and Tnni3
 Myl2 sirna  >11 publications with ACTC1 and Myl2
 Tpm1 sirna  >11 publications with ACTC1 and Tpm1
 Myl3 sirna  >10 publications with ACTC1 and Myl3
 Myh6 sirna  >7 publications with ACTC1 and Myh6
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with ACTC1 sirnaOrgans/Tissues associated with ACTC1 sirna
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >32 publications with ACTC1 and Cardiovascular Diseases
 Cardiomyopathy, Dilated Antibodies  >9 publications with ACTC1 and Cardiomyopathy, Dilated
 Cardiomegaly Antibodies  >6 publications with ACTC1 and Cardiomegaly
 Cardiomyopathy, Familial Hypertrophic, 1 Antibodies  >5 publications with ACTC1 and Cardiomyopathy, Familial Hypertrophic, 1
 Hypertrophy Antibodies  >4 publications with ACTC1 and Hypertrophy
 Disease Models, Animal Antibodies  >2 publications with ACTC1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >2 publications with ACTC1 and Lung Neoplasms
 Lung Diseases Antibodies  >2 publications with ACTC1 and Lung Diseases
 Refractive Errors Antibodies  >2 publications with ACTC1 and Refractive Errors
 Cardiomyopathy, Familial Hypertrophic, 11 Antibodies  >2 publications with ACTC1 and Cardiomyopathy, Familial Hypertrophic, 11
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >36 publications with ACTC1 and Heart
 Muscle Antibodies  >35 publications with ACTC1 and Muscle
 Embryonic Tissue Antibodies  >5 publications with ACTC1 and Embryonic Tissue
 Prostate Antibodies  >1 publications with ACTC1 and Prostate
 Uterus Antibodies  >1 publications with ACTC1 and Uterus
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