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ADAM8 sirna

Scan QR to view Datasheet Catalog #    MBS8238313 ADAM8 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAM8, siRNA

 Also Known As   

ADAM8 siRNA (Human)

 Product Synonym Names    MS2; Disintegrin and metalloproteinase domain-containing protein 8; ADAM 8; Cell surface antigen MS2; CD antigen CD156a
 Product Gene Name   

ADAM8 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602267
 3D Structure    ModBase 3D Structure for P78325
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    ADAM8 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human ADAM8 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of ADAM8 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for ADAM8 sirna

   siRNA to inhibit ADAM8 expression using RNA interference
 Applications Tested/Suitable for ADAM8 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ADAM8. It may not necessarily be applicable to this product.
 NCBI GI #    256773264
 NCBI GeneID    101
 NCBI Accession #    NP_001100.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001109.4 [Other Products]
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 UniProt Primary Accession #    P78325 [Other Products]
 UniProt Secondary Accession #    B4DVM6; H0YL36; H0YLR0; H0YN39 [Other Products]
 UniProt Related Accession #    P78325 [Other Products]
 Molecular Weight    80,262 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 8 isoform 1
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 8
 NCBI Official Symbol    ADAM8 [Similar Products]
 NCBI Official Synonym Symbols   
MS2; CD156; CD156a
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 8
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 8
 UniProt Synonym Protein Names   
Cell surface antigen MS2; CD_antigen: CD156a
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM8 [Similar Products]
 UniProt Synonym Gene Names    MS2; ADAM 8 [Similar Products]
 UniProt Entry Name    ADAM8_HUMAN
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 NCBI Summary for ADAM8    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]
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 UniProt Comments for ADAM8    ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: Protease; EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: specific granule; cell surface; integral to plasma membrane; cytoplasm; plasma membrane; podosome; dense core granule membrane

Molecular Function: protein binding; protein self-association; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding; cell adhesion molecule binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of cell adhesion; cell morphogenesis; proteolysis; positive regulation of membrane protein ectodomain proteolysis; leukocyte migration during inflammatory response; activation of NF-kappaB transcription factor; positive regulation of T cell differentiation in the thymus; positive regulation of protein kinase B signaling cascade; extracellular matrix disassembly; cell-cell adhesion; regulation of cell-cell adhesion; positive regulation of protein secretion; positive regulation of acute inflammatory response; positive regulation of bone resorption; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; lymphocyte chemotaxis
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 Research Articles on ADAM8    1. Data indicate that fibronectin fragments (FN-fs) are present in adult ntervertebral disc (IVD) from adult subjects, and ADAM-8, known to cleave FN, is present at the pericellular matrix of disc cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAM8 sirnaPathways associated with ADAM8 sirna
 Reference Product  PubMed Publications
 IL13 sirna  >2 publications with ADAM8 and IL13
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with ADAM8 sirnaOrgans/Tissues associated with ADAM8 sirna
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >40 publications with ADAM8 and Inflammation
 Lung Diseases Antibodies  >22 publications with ADAM8 and Lung Diseases
 Necrosis Antibodies  >19 publications with ADAM8 and Necrosis
 Disease Models, Animal Antibodies  >13 publications with ADAM8 and Disease Models, Animal
 Liver Diseases Antibodies  >7 publications with ADAM8 and Liver Diseases
 Lung Neoplasms Antibodies  >6 publications with ADAM8 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >6 publications with ADAM8 and Carcinoma, Hepatocellular
 Fibrosis Antibodies  >6 publications with ADAM8 and Fibrosis
 Liver Neoplasms Antibodies  >5 publications with ADAM8 and Liver Neoplasms
 Pneumonia Antibodies  >5 publications with ADAM8 and Pneumonia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >46 publications with ADAM8 and Blood
 Lung Antibodies  >23 publications with ADAM8 and Lung
 Brain Antibodies  >16 publications with ADAM8 and Brain
 Connective Tissue Antibodies  >7 publications with ADAM8 and Connective Tissue
 Kidney Antibodies  >6 publications with ADAM8 and Kidney
 Bone Marrow Antibodies  >6 publications with ADAM8 and Bone Marrow
 Stomach Antibodies  >5 publications with ADAM8 and Stomach
 Eye Antibodies  >2 publications with ADAM8 and Eye
 Spleen Antibodies  >2 publications with ADAM8 and Spleen
 Prostate Antibodies  >2 publications with ADAM8 and Prostate
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