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AGPAT2 sirna

Scan QR to view Datasheet Catalog #    MBS828602 AGPAT2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AGPAT2, siRNA

 Also Known As   

AGPAT2 siRNA (Mouse)

 Product Synonym Names    1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2; Lysophosphatidic acid acyltransferase beta; LPAAT-beta
 Product Gene Name   

AGPAT2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8K3K7
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    AGPAT2 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse AGPAT2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of AGPAT2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for AGPAT2 sirna

   siRNA to inhibit AGPAT2 expression using RNA interference
 Applications Tested/Suitable for AGPAT2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for AGPAT2. It may not necessarily be applicable to this product.
 NCBI GI #    23956162
 NCBI GeneID    67512
 NCBI Accession #    NP_080488.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_026212.2 [Other Products]
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 UniProt Primary Accession #    Q8K3K7 [Other Products]
 UniProt Related Accession #    Q8K3K7 [Other Products]
 Molecular Weight    31,011 Da
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 NCBI Official Full Name    1-acyl-sn-glycerol-3-phosphate acyltransferase beta
 NCBI Official Synonym Full Names    1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
 NCBI Official Symbol    Agpat2 [Similar Products]
 NCBI Official Synonym Symbols   
BSCL; BSCL1; LPAAB; AV000834; LPAAT-beta; 2510002J07Rik
[Similar Products]
 NCBI Protein Information    1-acyl-sn-glycerol-3-phosphate acyltransferase beta
 UniProt Protein Name    1-acyl-sn-glycerol-3-phosphate acyltransferase beta
 UniProt Synonym Protein Names   
1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2; Lysophosphatidic acid acyltransferase beta; LPAAT-beta
 Protein Family    1-acyl-sn-glycerol-3-phosphate acyltransferase
 UniProt Gene Name    Agpat2 [Similar Products]
 UniProt Synonym Gene Names    1-AGP acyltransferase 2; 1-AGPAT 2; LPAAT-beta [Similar Products]
 UniProt Entry Name    PLCB_MOUSE
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 UniProt Comments for AGPAT2    AGPAT2: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1); also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; Membrane protein, multi-pass; Lipid Metabolism - ether lipid; EC 2.3.1.51; Transferase; Membrane protein, integral

Cellular Component: membrane; endoplasmic reticulum; integral to membrane

Molecular Function: transferase activity; transferase activity, transferring acyl groups; 1-acylglycerol-3-phosphate O-acyltransferase activity

Biological Process: positive regulation of cytokine production; metabolic process; phosphatidic acid biosynthetic process; lipid metabolic process; phospholipid biosynthetic process
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 Research Articles on AGPAT2    1. Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AGPAT2 sirnaPathways associated with AGPAT2 sirna
 Reference Product  PubMed Publications
 Lpin1 sirna  >3 publications with AGPAT2 and Lpin1
 Lpin2 sirna  >1 publications with AGPAT2 and Lpin2
 Agpat9 sirna  >1 publications with AGPAT2 and Agpat9
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 CDP-diacylglycerol Biosynthesis I Pathway antibodies  CDP-diacylglycerol Biosynthesis I Pathway Diagram
 CDP-diacylglycerol Biosynthesis II Pathway antibodies  CDP-diacylglycerol Biosynthesis II Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
Diseases associated with AGPAT2 sirnaOrgans/Tissues associated with AGPAT2 sirna
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >56 publications with AGPAT2 and Skin Diseases
 Lipodystrophy, Congenital Generalized Antibodies  >52 publications with AGPAT2 and Lipodystrophy, Congenital Generalized
 Liver Diseases Antibodies  >15 publications with AGPAT2 and Liver Diseases
 Hypertrophy Antibodies  >13 publications with AGPAT2 and Hypertrophy
 Congenital Abnormalities Antibodies  >10 publications with AGPAT2 and Congenital Abnormalities
 Hepatomegaly Antibodies  >7 publications with AGPAT2 and Hepatomegaly
 Fatty Liver Antibodies  >6 publications with AGPAT2 and Fatty Liver
 Heart Diseases Antibodies  >5 publications with AGPAT2 and Heart Diseases
 Kidney Diseases Antibodies  >4 publications with AGPAT2 and Kidney Diseases
 Nervous System Diseases Antibodies  >4 publications with AGPAT2 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >19 publications with AGPAT2 and Liver
 Muscle Antibodies  >16 publications with AGPAT2 and Muscle
 Connective Tissue Antibodies  >13 publications with AGPAT2 and Connective Tissue
 Kidney Antibodies  >6 publications with AGPAT2 and Kidney
 Ovary Antibodies  >4 publications with AGPAT2 and Ovary
 Heart Antibodies  >3 publications with AGPAT2 and Heart
 Bone Marrow Antibodies  >3 publications with AGPAT2 and Bone Marrow
 Skin Antibodies  >3 publications with AGPAT2 and Skin
 Embryonic Tissue Antibodies  >2 publications with AGPAT2 and Embryonic Tissue
 Joint Antibodies  >2 publications with AGPAT2 and Joint
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