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AHI1 sirna

Scan QR to view Datasheet Catalog #    MBS8218233 AHI1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

AHI1 siRNA (Human)

 Product Synonym Names    Jouberin; Abelson helper integration site 1 protein homolog; AHI-1
 Product Gene Name   

AHI1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608629
 3D Structure    ModBase 3D Structure for Q8N157
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    AHI1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human AHI1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of AHI1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AHI1 sirna

   siRNA to inhibit AHI1 expression using RNA interference
 Applications Tested/Suitable for AHI1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for AHI1. It may not necessarily be applicable to this product.
 NCBI GI #    199559438
 NCBI GeneID    54806
 NCBI Accession #    NP_001128302.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001134830.1 [Other Products]
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 UniProt Primary Accession #    Q8N157 [Other Products]
 UniProt Secondary Accession #    Q4FD35; Q504T3; Q5TCP9; Q6P098; Q6PIT6; Q8NDX0; Q9H0H2; E1P584 [Other Products]
 UniProt Related Accession #    Q8N157 [Other Products]
 Molecular Weight    70,047 Da
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 NCBI Official Full Name    jouberin isoform a
 NCBI Official Synonym Full Names    Abelson helper integration site 1
 NCBI Official Symbol    AHI1 [Similar Products]
 NCBI Official Synonym Symbols   
ORF1; AHI-1; JBTS3; dJ71N10.1
[Similar Products]
 NCBI Protein Information    jouberin
 UniProt Protein Name    Jouberin
 UniProt Synonym Protein Names   
Abelson helper integration site 1 protein homolog; AHI-1
 Protein Family    Jouberin
 UniProt Gene Name    AHI1 [Similar Products]
 UniProt Synonym Gene Names    AHI-1 [Similar Products]
 UniProt Entry Name    AHI1_HUMAN
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 NCBI Summary for AHI1    This gene is apparently required for both cerebellar and cortical development in humans. This gene mutations cause specific forms of Joubert syndrome-related disorders. Joubert syndrome (JS) is a recessively inherited developmental brain disorder with several identified causative chromosomal loci. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
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 UniProt Comments for AHI1    AHI1: is up-regulated at all stages of chronic myeloid leukemia (CML). Down-regulated during early differentiation of normal hematopoietic cells. The AHI-1 gene is activated by insertional mutagenesis in mouse models of leukemia. Important for cerebellar and cortical development, and axonal decussation. Mutations of the AHI-1 gene are associated with Joubert syndrome. Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Genetic analysis indicates that it is important in the development of human-specific motor behaviors. Three alternatively spliced isoforms have been described.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: centriole; centrosome; adherens junction; photoreceptor outer segment; nonmotile primary cilium; intercellular junction; cilium

Molecular Function: identical protein binding; protein binding

Biological Process: positive regulation of polarized epithelial cell differentiation; central nervous system development; vesicle targeting; positive regulation of receptor internalization; specification of axis polarity; vesicle-mediated transport; protein localization in organelle; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; heart looping; transmembrane receptor protein tyrosine kinase signaling pathway; morphogenesis of a polarized epithelium; negative regulation of apoptosis; hindbrain development; regulation of behavior

Disease: Joubert Syndrome 3
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 Research Articles on AHI1    1. Joubert syndrome-associated missense mutations alter the subcellular distribution and protein interactions of AHI1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AHI1 sirnaDiseases associated with AHI1 sirna
 Reference Product  PubMed Publications
 NPHP1 sirna  >21 publications with AHI1 and NPHP1
 CEP290 sirna  >18 publications with AHI1 and CEP290
 TMEM67 sirna  >11 publications with AHI1 and TMEM67
 CC2D2A sirna  >10 publications with AHI1 and CC2D2A
 MKS1 sirna  >5 publications with AHI1 and MKS1
 MYB sirna  >5 publications with AHI1 and MYB
 HAP1 sirna  >4 publications with AHI1 and HAP1
 B9D1 sirna  >2 publications with AHI1 and B9D1
 TMEM216 sirna  >2 publications with AHI1 and TMEM216
 B9D2 sirna  >1 publications with AHI1 and B9D2
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >24 publications with AHI1 and Kidney Diseases
 Abnormalities, Multiple Antibodies  >21 publications with AHI1 and Abnormalities, Multiple
 Cerebellar Diseases Antibodies  >21 publications with AHI1 and Cerebellar Diseases
 Schizophrenia Antibodies  >13 publications with AHI1 and Schizophrenia
 Retinal Degeneration Antibodies  >10 publications with AHI1 and Retinal Degeneration
 Joubert syndrome 3 Antibodies  >10 publications with AHI1 and Joubert syndrome 3
 Immune System Diseases Antibodies  >7 publications with AHI1 and Immune System Diseases
 Fibrosis Antibodies  >6 publications with AHI1 and Fibrosis
 Diabetes Mellitus Antibodies  >5 publications with AHI1 and Diabetes Mellitus
 Intellectual Disability Antibodies  >5 publications with AHI1 and Intellectual Disability
Organs/Tissues associated with AHI1 sirna
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >46 publications with AHI1 and Brain
 Kidney Antibodies  >30 publications with AHI1 and Kidney
 Eye Antibodies  >23 publications with AHI1 and Eye
 Blood Antibodies  >12 publications with AHI1 and Blood
 Nerve Antibodies  >11 publications with AHI1 and Nerve
 Liver Antibodies  >7 publications with AHI1 and Liver
 Bone Antibodies  >6 publications with AHI1 and Bone
 Embryonic Tissue Antibodies  >3 publications with AHI1 and Embryonic Tissue
 Bone Marrow Antibodies  >3 publications with AHI1 and Bone Marrow
 Skin Antibodies  >3 publications with AHI1 and Skin
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