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ALOX12 sirna

Scan QR to view Datasheet Catalog #    MBS8207008 ALOX12 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALOX12, siRNA

 Also Known As   

ALOX12 siRNA (Human)

 Product Synonym Names    12LO; LOG12; Arachidonate 12-lipoxygenase. 12S-type; 12S-LOX; 12S-lipoxygenase; Lipoxin synthase 12-LO; Platelet-type lipoxygenase 12
 Product Gene Name   

ALOX12 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    114500
 3D Structure    ModBase 3D Structure for P18054
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    ALOX12 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human ALOX12 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of ALOX12 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ALOX12 sirna

   siRNA to inhibit ALOX12 expression using RNA interference
 Applications Tested/Suitable for ALOX12 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for ALOX12. It may not necessarily be applicable to this product.
 NCBI GI #    154426292
 NCBI GeneID    239
 NCBI Accession #    NP_000688.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000697.2 [Other Products]
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 UniProt Primary Accession #    P18054 [Other Products]
 UniProt Secondary Accession #    O95569; Q6ISF8; Q9UQM4 [Other Products]
 UniProt Related Accession #    P18054 [Other Products]
 Molecular Weight    75,694 Da
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 NCBI Official Full Name    arachidonate 12-lipoxygenase, 12S-type
 NCBI Official Synonym Full Names    arachidonate 12-lipoxygenase
 NCBI Official Symbol    ALOX12 [Similar Products]
 NCBI Official Synonym Symbols   
LOG12; 12-LOX; 12S-LOX
[Similar Products]
 NCBI Protein Information    arachidonate 12-lipoxygenase, 12S-type
 UniProt Protein Name    Arachidonate 12-lipoxygenase, 12S-type
 UniProt Synonym Protein Names   
Lipoxin synthase 12-LO (EC:3.3.2.-); Platelet-type lipoxygenase 12
 Protein Family    Arachidonate 12-lipoxygenase
 UniProt Gene Name    ALOX12 [Similar Products]
 UniProt Synonym Gene Names    12LO; LOG12; 12S-LOX; 12S-lipoxygenase [Similar Products]
 UniProt Entry Name    LOX12_HUMAN
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 UniProt Comments for ALOX12    ALOX12: Oxygenase and 14,15-leukotriene A4 synthase activity. Belongs to the lipoxygenase family.

Protein type: Apoptosis; Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.13.11.31

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane; cytoplasm; cytosol; sarcolemma

Molecular Function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; arachidonate 12-lipoxygenase activity; hepoxilin A3 synthase activity; protein binding; hepoxilin-epoxide hydrolase activity; lipoxygenase activity; iron ion binding

Biological Process: positive regulation of cell adhesion; positive regulation of smooth muscle cell proliferation; linoleic acid metabolic process; positive regulation of caspase activity; positive regulation of vasodilation; positive regulation of cell growth; positive regulation of angiogenesis; positive regulation of endothelial cell differentiation; lipoxygenase pathway; positive regulation of mitochondrial depolarization; positive regulation of cell proliferation; arachidonic acid metabolic process; fatty acid oxidation; hepoxilin biosynthetic process; cell motility; superoxide release; hepoxilin metabolic process; positive regulation of cell migration; aging; negative regulation of apoptosis
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 Research Articles on ALOX12    1. The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ALOX12 sirnaPathways associated with ALOX12 sirna
 Reference Product  PubMed Publications
 PTGS2 sirna  >11 publications with ALOX12 and PTGS2
 PTGS1 sirna  >7 publications with ALOX12 and PTGS1
 PLA2G4A sirna  >1 publications with ALOX12 and PLA2G4A
 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
Diseases associated with ALOX12 sirnaOrgans/Tissues associated with ALOX12 sirna
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >20 publications with ALOX12 and Inflammation
 Cardiovascular Diseases Antibodies  >16 publications with ALOX12 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >9 publications with ALOX12 and Nervous System Diseases
 Skin Diseases Antibodies  >7 publications with ALOX12 and Skin Diseases
 Leukemia Antibodies  >4 publications with ALOX12 and Leukemia
 Lung Diseases Antibodies  >4 publications with ALOX12 and Lung Diseases
 Hypertension Antibodies  >3 publications with ALOX12 and Hypertension
 Necrosis Antibodies  >2 publications with ALOX12 and Necrosis
 Pneumonia Antibodies  >2 publications with ALOX12 and Pneumonia
 Breast Neoplasms Antibodies  >2 publications with ALOX12 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with ALOX12 and Skin
 Lung Antibodies  >3 publications with ALOX12 and Lung
 Muscle Antibodies  >2 publications with ALOX12 and Muscle
 Connective Tissue Antibodies  >2 publications with ALOX12 and Connective Tissue
 Embryonic Tissue Antibodies  >2 publications with ALOX12 and Embryonic Tissue
 Ovary Antibodies  >1 publications with ALOX12 and Ovary
 Intestine Antibodies  >1 publications with ALOX12 and Intestine
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