NP_001190994.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
44,522 Da
NCBI Official Full Name
ankyrin repeat and sterile alpha motif domain-containing protein 1B isoform d
NCBI Official Synonym Full Names
ankyrin repeat and sterile alpha motif domain containing 1B
NCBI Official Synonym Symbols
EB1; AIDA; EB-1; ANKS2; AIDA-1; cajalin-2 [Similar Products]
NCBI Protein Information
ankyrin repeat and sterile alpha motif domain-containing protein 1B
UniProt Protein Name
Ankyrin repeat and sterile alpha motif domain-containing protein 1B
UniProt Synonym Protein Names
Amyloid-beta protein intracellular domain-associated protein 1; AIDA-1; E2A-PBX1-associated protein; EB-1
UniProt Synonym Gene Names
UniProt Entry Name
ANS1B_HUMAN
NCBI Summary for ANKS1B
This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for ANKS1B
AIDA-1b: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion
Chromosomal Location of Human Ortholog: 12q23.1
Cellular Component: Cajal body; postsynaptic membrane; postsynaptic density; cytoplasm; dendritic spine; cell junction
Molecular Function: ephrin receptor binding
Research Articles on ANKS1B
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Diseases associated with ANKS1B sirna
Organs/Tissues associated with ANKS1B sirna
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