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APOA2 sirna

Scan QR to view Datasheet Catalog #    MBS8241220 APOA2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APOA2, siRNA

 Also Known As   

APOA2 siRNA (Human)

 Product Synonym Names    Apolipoprotein A-II; Apo-AII; ApoA-II; Apolipoprotein A2
 Product Gene Name   

APOA2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107670
 3D Structure    ModBase 3D Structure for P02652
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    APOA2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human APOA2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of APOA2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for APOA2 sirna

   siRNA to inhibit APOA2 expression using RNA interference
 Applications Tested/Suitable for APOA2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for APOA2. It may not necessarily be applicable to this product.
 NCBI GI #    4502149
 NCBI GeneID    336
 NCBI Accession #    NP_001634.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001643.1 [Other Products]
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 UniProt Primary Accession #    P02652 [Other Products]
 UniProt Secondary Accession #    B2R524 [Other Products]
 UniProt Related Accession #    P02652 [Other Products]
 Molecular Weight    11,175 Da
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 NCBI Official Full Name    apolipoprotein A-II preproprotein
 NCBI Official Synonym Full Names    apolipoprotein A-II
 NCBI Official Symbol    APOA2 [Similar Products]
 NCBI Official Synonym Symbols   
apoAII; Apo-AII; ApoA-II
[Similar Products]
 NCBI Protein Information    apolipoprotein A-II
 UniProt Protein Name    Apolipoprotein A-II
 UniProt Synonym Protein Names   
Apolipoprotein A2
 Protein Family    Apolipoprotein
 UniProt Gene Name    APOA2 [Similar Products]
 UniProt Synonym Gene Names    Apo-AII; ApoA-II; ProapoA-II [Similar Products]
 UniProt Entry Name    APOA2_HUMAN
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 NCBI Summary for APOA2    This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APOA2    APOA2: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Belongs to the apolipoprotein A2 family.

Protein type: Secreted; Lipid-binding; Secreted, signal peptide; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: chylomicron; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol

Molecular Function: lipid transporter activity; protein binding; protein homodimerization activity; lipase inhibitor activity; protein heterodimerization activity; cholesterol transporter activity; cholesterol binding; phospholipid binding; phosphatidylcholine binding; lipid binding; high-density lipoprotein binding; apolipoprotein receptor binding

Biological Process: positive regulation of catalytic activity; phototransduction, visible light; protein folding; viral reproduction; negative regulation of cholesterol transport; response to glucocorticoid stimulus; regulation of protein stability; diacylglycerol catabolic process; positive regulation of lipid catabolic process; cellular lipid metabolic process; negative regulation of lipase activity; negative regulation of lipid catabolic process; phospholipid efflux; regulation of cholesterol absorption; response to glucose stimulus; retinoid metabolic process; response to drug; cholesterol metabolic process; organ regeneration; protein amino acid oxidation; phospholipid catabolic process; positive regulation of interleukin-8 biosynthetic process; cholesterol efflux; lipoprotein metabolic process; negative regulation of cytokine secretion during immune response; cholesterol homeostasis; reverse cholesterol transport; triacylglycerol metabolic process; response to estrogen stimulus; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; acute inflammatory response

Disease: Hypercholesterolemia, Familial
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 Research Articles on APOA2    1. Apolipoprotein A-II/B significantly improves risk prediction of overall survival, also in carotid surgery patients with lower LDL levels
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with APOA2 sirnaPathways associated with APOA2 sirna
 Reference Product  PubMed Publications
 APOA1 sirna  >44 publications with APOA2 and APOA1
 APOE sirna  >21 publications with APOA2 and APOE
 APOB sirna  >20 publications with APOA2 and APOB
 APOC3 sirna  >16 publications with APOA2 and APOC3
 APOA4 sirna  >6 publications with APOA2 and APOA4
 LPL sirna  >6 publications with APOA2 and LPL
 APOA5 sirna  >4 publications with APOA2 and APOA5
 LDLR sirna  >2 publications with APOA2 and LDLR
 MTTP sirna  >1 publications with APOA2 and MTTP
 Products by Pathway  Pathway Diagram
 Chylomicron-mediated Lipid Transport Pathway antibodies  Chylomicron-mediated Lipid Transport Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
Diseases associated with APOA2 sirnaOrgans/Tissues associated with APOA2 sirna
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >25 publications with APOA2 and Cardiovascular Diseases
 Dyslipidemias Antibodies  >17 publications with APOA2 and Dyslipidemias
 Heart Diseases Antibodies  >16 publications with APOA2 and Heart Diseases
 Liver Diseases Antibodies  >15 publications with APOA2 and Liver Diseases
 Hyperlipidemias Antibodies  >13 publications with APOA2 and Hyperlipidemias
 Insulin Resistance Antibodies  >10 publications with APOA2 and Insulin Resistance
 Kidney Diseases Antibodies  >9 publications with APOA2 and Kidney Diseases
 Inflammation Antibodies  >9 publications with APOA2 and Inflammation
 Liver Neoplasms Antibodies  >6 publications with APOA2 and Liver Neoplasms
 Hepatitis Antibodies  >6 publications with APOA2 and Hepatitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with APOA2 and Blood
 Liver Antibodies  >28 publications with APOA2 and Liver
 Heart Antibodies  >16 publications with APOA2 and Heart
 Kidney Antibodies  >11 publications with APOA2 and Kidney
 Muscle Antibodies  >7 publications with APOA2 and Muscle
 Intestine Antibodies  >5 publications with APOA2 and Intestine
 Brain Antibodies  >3 publications with APOA2 and Brain
 Placenta Antibodies  >3 publications with APOA2 and Placenta
 Lung Antibodies  >2 publications with APOA2 and Lung
 Spleen Antibodies  >2 publications with APOA2 and Spleen
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