NP_001229977.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,061 Da
NCBI Official Full Name
aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform 2
NCBI Official Synonym Full Names
aryl hydrocarbon receptor nuclear translocator-like
NCBI Official Synonym Symbols
MOP3; Arnt3; Bmal1; BMAL1b; bHLHe5; bmal1b' [Similar Products]
NCBI Protein Information
aryl hydrocarbon receptor nuclear translocator-like protein 1
UniProt Protein Name
Aryl hydrocarbon receptor nuclear translocator-like protein 1
UniProt Synonym Protein Names
Arnt3; Brain and muscle ARNT-like 1
UniProt Synonym Gene Names
UniProt Entry Name
BMAL1_MOUSE
NCBI Summary for ARNTL
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with Clock. This heterodimer binds E-box enhancer elements upstream of Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2) genes and activates transcription of these genes. Per and Cry proteins heterodimerize and repress their own transcription by interacting in a feedback loop with Clock/Arntl complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2014]
UniProt Comments for ARNTL
BMAL1: aryl hydrocarbon receptor nuclear translocator-like protein. A circadian regulatory protein and substrate of casein kinase I epsilon. Heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Seven splice isoforms have been reported.
Protein type: DNA-binding; Transcription factor
Cellular Component: nuclear body; transcription factor complex; cytoplasm; nucleus
Molecular Function: protein dimerization activity; protein binding; signal transducer activity; DNA binding; aryl hydrocarbon receptor binding; sequence-specific DNA binding; protein heterodimerization activity; bHLH transcription factor binding; Hsp90 protein binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; circadian rhythm; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; transcription, DNA-dependent; regulation of cell cycle; positive regulation of transcription, DNA-dependent; rhythmic process; response to redox state; positive regulation of circadian rhythm; signal transduction; negative regulation of fat cell differentiation; regulation of neurogenesis; regulation of transcription, DNA-dependent; protein import into nucleus, translocation; regulation of protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; regulation of insulin secretion; regulation of hair cycle
Research Articles on ARNTL
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Products associated with ARNTL sirna
Pathways associated with ARNTL sirna
Diseases associated with ARNTL sirna
Organs/Tissues associated with ARNTL sirna
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