NP_077375.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,314 Da
NCBI Official Full Name
aspartoacylase
NCBI Official Synonym Full Names
aspartoacylase
NCBI Protein Information
aspartoacylase
UniProt Protein Name
Aspartoacylase
UniProt Synonym Protein Names
Aminoacylase-2; ACY-2
UniProt Synonym Gene Names
UniProt Entry Name
ACY2_RAT
NCBI Summary for ASPA
catalyzes the deacetylation of N-acetylaspartate to free acetate; may play a role in central nervous system myelination [RGD, Feb 2006]
UniProt Comments for ASPA
ASPA: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids. Defects in ASPA are the cause of Canavan disease (CAND); also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average. Belongs to the AspA/AstE family. Aspartoacylase subfamily.
Protein type: Hydrolase; Cell development/differentiation; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 3.5.1.15; Amino Acid Metabolism - histidine
Cellular Component: cytoplasm; cytosol; nucleus
Molecular Function: metal ion binding; hydrolase activity, acting on ester bonds; aspartoacylase activity
Biological Process: metabolic process; myelination in the central nervous system; positive regulation of oligodendrocyte differentiation
Research Articles on ASPA
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Products associated with ASPA sirna
Pathways associated with ASPA sirna
Diseases associated with ASPA sirna
Organs/Tissues associated with ASPA sirna
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