NP_001135445.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
128,323 Da
NCBI Official Full Name
probable cation-transporting ATPase 13A2 isoform 2
NCBI Official Synonym Full Names
ATPase type 13A2
NCBI Protein Information
probable cation-transporting ATPase 13A2
UniProt Protein Name
Probable cation-transporting ATPase 13A2
UniProt Synonym Gene Names
UniProt Entry Name
AT132_HUMAN
NCBI Summary for ATP13A2
This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
UniProt Comments for ATP13A2
ATP13A2: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Transporter, ion channel; Membrane protein, integral; EC 3.6.3.-; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: lysosomal membrane; lysosome; integral to membrane
Molecular Function: protein binding; metal ion binding; ATPase activity; ATP binding
Biological Process: metabolic process; cation transport
Disease: Kufor-rakeb Syndrome
Research Articles on ATP13A2
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Products associated with ATP13A2 sirna
Diseases associated with ATP13A2 sirna
Organs/Tissues associated with ATP13A2 sirna
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