NP_000692.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
113,000 Da
NCBI Official Full Name
sodium/potassium-transporting ATPase subunit alpha-1 isoform a
NCBI Official Synonym Full Names
ATPase, Na+/K+ transporting, alpha 1 polypeptide
NCBI Protein Information
sodium/potassium-transporting ATPase subunit alpha-1
UniProt Protein Name
Sodium/potassium-transporting ATPase subunit alpha-1
UniProt Synonym Protein Names
Sodium pump subunit alpha-1
UniProt Synonym Gene Names
UniProt Entry Name
AT1A1_HUMAN
NCBI Summary for ATP1A1
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for ATP1A1
ATP1A1: the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Two splice-variant isoforms have been described.
Protein type: Membrane protein, integral; EC 3.6.3.9; Transporter, ion channel; Transporter; Hydrolase; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p21
Cellular Component: Golgi apparatus; protein complex; basolateral plasma membrane; endoplasmic reticulum; T-tubule; integral to membrane; caveola; membrane; apical plasma membrane; plasma membrane; melanosome; sodium:potassium-exchanging ATPase complex; vesicle; sarcolemma; endosome
Molecular Function: potassium ion binding; protein domain specific binding; protein binding; sodium ion binding; chaperone binding; phosphoric monoester hydrolase activity; sodium:potassium-exchanging ATPase activity; phosphoinositide 3-kinase binding; ankyrin binding; ADP binding; protein kinase binding; ATP binding
Biological Process: response to drug; cellular sodium ion homeostasis; negative regulation of heart contraction; membrane hyperpolarization; positive regulation of striated muscle contraction; regulation of sodium ion transport; cellular potassium ion homeostasis; negative regulation of glucocorticoid biosynthetic process; potassium ion import; dephosphorylation; regulation of blood pressure; transmembrane transport; positive regulation of heart contraction; regulation of the force of heart contraction; cardiac muscle contraction
Research Articles on ATP1A1
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Products associated with ATP1A1 sirna
Pathways associated with ATP1A1 sirna
Diseases associated with ATP1A1 sirna
Organs/Tissues associated with ATP1A1 sirna
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