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BACH1 sirna

Scan QR to view Datasheet Catalog #    MBS8216943 BACH1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BACH1, siRNA

 Also Known As   

BACH1 siRNA (Human)

 Product Synonym Names    Transcription regulator protein BACH1; BTB and CNC homolog 1; HA2303
 Product Gene Name   

BACH1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602751
 3D Structure    ModBase 3D Structure for O14867
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    BACH1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human BACH1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of BACH1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BACH1 sirna

   siRNA to inhibit BACH1 expression using RNA interference
 Applications Tested/Suitable for BACH1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for BACH1. It may not necessarily be applicable to this product.
 NCBI GI #    4502353
 NCBI GeneID    571
 NCBI Accession #    NP_001177.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001186.3 [Other Products]
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 UniProt Primary Accession #    O14867 [Other Products]
 UniProt Secondary Accession #    O43285; Q6ICU0 [Other Products]
 UniProt Related Accession #    O14867 [Other Products]
 Molecular Weight    81,958 Da
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 NCBI Official Full Name    transcription regulator protein BACH1
 NCBI Official Synonym Full Names    BTB and CNC homology 1, basic leucine zipper transcription factor 1
 NCBI Official Symbol    BACH1 [Similar Products]
 NCBI Official Synonym Symbols   
BACH-1; BTBD24
[Similar Products]
 NCBI Protein Information    transcription regulator protein BACH1
 UniProt Protein Name    Transcription regulator protein BACH1
 UniProt Synonym Protein Names   
BTB and CNC homolog 1; HA2303
 Protein Family    Transcription regulator protein
 UniProt Gene Name    BACH1 [Similar Products]
 UniProt Entry Name    BACH1_HUMAN
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 NCBI Summary for BACH1    This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
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 UniProt Comments for BACH1    BACH1: a transcriptional regulator that acts as a repressor or activator. Binds, in-vitro, to NF-E2 binding sites on DNA. Plays an important role in coordinating transcription activation and repression by NF-E2. Belongs to the bZIP family, CNC subfamily.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus

Molecular Function: heme binding; transcription factor activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; G2/M-specific transcription in mitotic cell cycle
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 Research Articles on BACH1    1. Higher HMOX1 expression correlated with higher expression of Bach-1 (Spearman's rho = 0.586, p = 0.000001) and miR-122 (Spearman's rho = 0.270, p = 0.014059).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BACH1 sirnaPathways associated with BACH1 sirna
 Reference Product  PubMed Publications
 BRCA1 sirna  >73 publications with BACH1 and BRCA1
 MAFK sirna  >19 publications with BACH1 and MAFK
 MLH1 sirna  >13 publications with BACH1 and MLH1
 BARD1 sirna  >6 publications with BACH1 and BARD1
 MAFG sirna  >5 publications with BACH1 and MAFG
 MMP1 sirna  >3 publications with BACH1 and MMP1
 MAFF sirna  >2 publications with BACH1 and MAFF
 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with BACH1 sirnaOrgans/Tissues associated with BACH1 sirna
 Disease Name  Pubmed Publications
 Anemia Antibodies  >178 publications with BACH1 and Anemia
 Nervous System Diseases Antibodies  >15 publications with BACH1 and Nervous System Diseases
 Inflammation Antibodies  >14 publications with BACH1 and Inflammation
 Liver Diseases Antibodies  >12 publications with BACH1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >12 publications with BACH1 and Cardiovascular Diseases
 Immune System Diseases Antibodies  >11 publications with BACH1 and Immune System Diseases
 Neoplasms, Experimental Antibodies  >9 publications with BACH1 and Neoplasms, Experimental
 Down Syndrome Antibodies  >9 publications with BACH1 and Down Syndrome
 Neurobehavioral Manifestations Antibodies  >6 publications with BACH1 and Neurobehavioral Manifestations
 Heart Diseases Antibodies  >6 publications with BACH1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >27 publications with BACH1 and Liver
 Blood Antibodies  >27 publications with BACH1 and Blood
 Bone Antibodies  >20 publications with BACH1 and Bone
 Lung Antibodies  >12 publications with BACH1 and Lung
 Vascular Antibodies  >12 publications with BACH1 and Vascular
 Brain Antibodies  >9 publications with BACH1 and Brain
 Skin Antibodies  >9 publications with BACH1 and Skin
 Muscle Antibodies  >5 publications with BACH1 and Muscle
 Kidney Antibodies  >3 publications with BACH1 and Kidney
 Intestine Antibodies  >2 publications with BACH1 and Intestine
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