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BEX1 sirna

Scan QR to view Datasheet Catalog #    MBS8212343 BEX1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

BEX1, siRNA

 Also Known As   

BEX1 siRNA (Mouse)

 Product Synonym Names    REX3; Protein BEX1; Brain-expressed X-linked protein 1 homolog; Reduced expression protein 3; REX-3
 Product Gene Name   

BEX1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9R224
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    BEX1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse BEX1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of BEX1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for BEX1 sirna

   siRNA to inhibit BEX1 expression using RNA interference
 Applications Tested/Suitable for BEX1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for BEX1. It may not necessarily be applicable to this product.
 NCBI GI #    47059482
 NCBI GeneID    19716
 NCBI Accession #    NP_033078.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_009052.2 [Other Products]
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 UniProt Primary Accession #    Q9R224 [Other Products]
 UniProt Secondary Accession #    O88858; Q9R1J2; A3KGA2 [Other Products]
 UniProt Related Accession #    Q9R224 [Other Products]
 Molecular Weight    15,119 Da
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 NCBI Official Full Name    protein BEX1
 NCBI Official Synonym Full Names    brain expressed gene 1
 NCBI Official Symbol    Bex1 [Similar Products]
 NCBI Official Synonym Symbols   
Bex4; Rex3; AA407839; AU018692
[Similar Products]
 NCBI Protein Information    protein BEX1
 UniProt Protein Name    Protein BEX1
 UniProt Synonym Protein Names   
Brain-expressed X-linked protein 1 homolog; Reduced expression protein 3; REX-3
 Protein Family    Protein
 UniProt Gene Name    Bex1 [Similar Products]
 UniProt Synonym Gene Names    Rex3; REX-3 [Similar Products]
 UniProt Entry Name    BEX1_MOUSE
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 UniProt Comments for BEX1    BEX1: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states. Belongs to the BEX family.

Protein type: Cell development/differentiation; Cell cycle regulation

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: nervous system development; positive regulation of neuroblast proliferation; negative regulation of neuron differentiation; nerve growth factor receptor signaling pathway; multicellular organismal development; cell differentiation
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 Research Articles on BEX1    1. Bex1 protein is over-expressed as a result of peripheral axonal damage and antagonizes the axon outgrowth inhibitory effect of myelin-associated glycoprotein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BEX1 sirnaDiseases associated with BEX1 sirna
 Reference Product  PubMed Publications
 Bex2 sirna  >14 publications with BEX1 and Bex2
 Ngfrap1 sirna  >5 publications with BEX1 and Ngfrap1
 Omp sirna  >4 publications with BEX1 and Omp
 Bex6 sirna  >1 publications with BEX1 and Bex6
 Pcdh10 sirna  >1 publications with BEX1 and Pcdh10
 Lmo2 sirna  >1 publications with BEX1 and Lmo2
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >3 publications with BEX1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >2 publications with BEX1 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with BEX1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >2 publications with BEX1 and Liver Diseases
 Chromosome Aberrations Antibodies  >2 publications with BEX1 and Chromosome Aberrations
 Cardiovascular Diseases Antibodies  >2 publications with BEX1 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with BEX1 and Necrosis
 Edema Antibodies  >1 publications with BEX1 and Edema
 Disease Models, Animal Antibodies  >1 publications with BEX1 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >1 publications with BEX1 and Cell Transformation, Neoplastic
Organs/Tissues associated with BEX1 sirna
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with BEX1 and Brain
 Embryonic Tissue Antibodies  >7 publications with BEX1 and Embryonic Tissue
 Liver Antibodies  >4 publications with BEX1 and Liver
 Heart Antibodies  >3 publications with BEX1 and Heart
 Spinal Cord Antibodies  >3 publications with BEX1 and Spinal Cord
 Pancreas Antibodies  >2 publications with BEX1 and Pancreas
 Eye Antibodies  >2 publications with BEX1 and Eye
 Kidney Antibodies  >2 publications with BEX1 and Kidney
 Testis Antibodies  >1 publications with BEX1 and Testis
 Extraembryonic Tissue Antibodies  >1 publications with BEX1 and Extraembryonic Tissue
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