NP_001020938.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
50,634 Da
NCBI Official Full Name
B-cell linker protein
NCBI Official Synonym Full Names
B-cell linker
NCBI Protein Information
B-cell linker protein
UniProt Protein Name
B-cell linker protein
UniProt Synonym Protein Names
Cytoplasmic adapter protein
UniProt Entry Name
BLNK_RAT
UniProt Comments for BLNK
BLNK: an adaptor protein that bridges the B-cell receptor-associated kinases (BCR) with a multitude of signaling pathways, regulating biologic outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2 ) mobilization. Does not seem to be not required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Its phosphorylation is required for both Ca(2 ) and MAPK signaling pathways. Defects in BLNK are the cause of hypoglobulinemia and absent B-cells.It has tumor supressor activity that is lost in many cases of childhood pre-B acute lymphoblastic leukemia (ALL). Two alternatively spliced isoforms have been described; these are differentially involved in activation and apoptosis of B lymphocytes.
Protein type: Adaptor/scaffold
Cellular Component: cytoplasm; plasma membrane
Molecular Function: SH3/SH2 adaptor activity
Biological Process: B cell activation; positive regulation of signal transduction
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Products associated with BLNK sirna
Pathways associated with BLNK sirna
Diseases associated with BLNK sirna
Organs/Tissues associated with BLNK sirna
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