NP_536706.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
33,813 Da
NCBI Official Full Name
barttin
NCBI Official Synonym Full Names
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
NCBI Protein Information
barttin
UniProt Protein Name
Barttin
UniProt Entry Name
BSND_MOUSE
UniProt Comments for BSND
BSND: Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter. Defects in BSND are the cause of Bartter syndrome type 4A (BS4A); also known as infantile Bartter syndrome with sensorineural deafness. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS4A is associated with sensorineural deafness.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Cellular Component: protein complex; membrane; cell; basolateral plasma membrane; integral to plasma membrane; integral to membrane; plasma membrane
Molecular Function: chloride channel activity; protein binding; chloride channel regulator activity
Biological Process: sensory perception of sound; cellular ion homeostasis; chloride transport; cellular chloride ion homeostasis; cellular potassium ion homeostasis
Research Articles on BSND
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Products associated with BSND sirna
Pathways associated with BSND sirna
Diseases associated with BSND sirna
Organs/Tissues associated with BSND sirna
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