NP_031600.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
25,992 Da
NCBI Official Full Name
complement C1q subcomponent subunit C
NCBI Official Synonym Full Names
complement component 1, q subcomponent, C chain
NCBI Protein Information
complement C1q subcomponent subunit C
UniProt Protein Name
Complement C1q subcomponent subunit C
UniProt Synonym Gene Names
UniProt Entry Name
C1QC_MOUSE
UniProt Comments for C1QC
C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular space; collagen; membrane; extracellular region
Molecular Function: tumor necrosis factor receptor binding
Biological Process: negative regulation of macrophage differentiation; immune system process; innate immune response; immune response; complement activation, classical pathway; negative regulation of granulocyte differentiation
Research Articles on C1QC
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Products associated with C1QC sirna
Pathways associated with C1QC sirna
Diseases associated with C1QC sirna
Organs/Tissues associated with C1QC sirna
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