NP_001020788.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,566 Da
NCBI Official Full Name
soluble calcium-activated nucleotidase 1 isoform a
NCBI Official Synonym Full Names
calcium activated nucleotidase 1
NCBI Official Synonym Symbols
Apy1h; Shapy; Entpd8; SCAN-1; D11Bwg0554e; 5830420C20Rik [Similar Products]
NCBI Protein Information
soluble calcium-activated nucleotidase 1
UniProt Protein Name
Soluble calcium-activated nucleotidase 1
UniProt Synonym Protein Names
Apyrase homolog
UniProt Synonym Gene Names
UniProt Entry Name
CANT1_MOUSE
NCBI Summary for CANT1
The protein encoded by this gene is a calcium-dependent nucleotidase that preferentially hydrolyzes UDP, GDP, and IDP. The encoded protein has low activity with ADP and ATP and shows no activity with AMP and GMP. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
UniProt Comments for CANT1
CANT1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Membrane protein, integral; EC 3.6.1.6; Endoplasmic reticulum; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine
Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane
Molecular Function: signal transducer activity; pyrophosphatase activity; hydrolase activity; metal ion binding; nucleoside-diphosphatase activity; guanosine-diphosphatase activity; calcium ion binding; uridine-diphosphatase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process; signal transduction; ribonucleoside diphosphate catabolic process
Research Articles on CANT1
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Pathways associated with CANT1 sirna
Diseases associated with CANT1 sirna
Organs/Tissues associated with CANT1 sirna
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