NP_071639.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,632 Da
NCBI Official Full Name
caspase recruitment domain-containing protein 9
NCBI Official Synonym Full Names
caspase recruitment domain family, member 9
NCBI Protein Information
caspase recruitment domain-containing protein 9
UniProt Protein Name
Caspase recruitment domain-containing protein 9
UniProt Synonym Gene Names
UniProt Entry Name
CARD9_RAT
NCBI Summary for CARD9
interacts with the CARD activation domain of BCL10; activates NF-kappaB signaling [RGD, Feb 2006]
UniProt Comments for CARD9
CARD9: Activates NF-kappa-B via BCL10. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2). Chronic mucocutaneous candidiasis is characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CANDF2 is an autosomal recessive chronic mucocutaneous candidiasis. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Cellular Component: cytoplasm
Molecular Function: protein domain specific binding; protein homodimerization activity; CARD domain binding
Biological Process: response to drug; I-kappaB kinase/NF-kappaB cascade; response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; regulation of interleukin-2 biosynthetic process; regulation of interleukin-6 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of tumor necrosis factor production; positive regulation of stress-activated MAPK cascade; activation of NF-kappaB transcription factor; regulation of apoptosis; defense response to Gram-positive bacterium; response to exogenous dsRNA; response to muramyl dipeptide; response to peptidoglycan; positive regulation of innate immune response; innate immune response; defense response to virus; regulation of tumor necrosis factor biosynthetic process
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Products associated with CARD9 sirna
Pathways associated with CARD9 sirna
Diseases associated with CARD9 sirna
Organs/Tissues associated with CARD9 sirna
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