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CDK5RAP3 sirna

Scan QR to view Datasheet Catalog #    MBS8207822 CDK5RAP3 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CDK5RAP3, siRNA

 Also Known As   

CDK5RAP3 siRNA (Human)

 Product Synonym Names    IC53; CDK5 regulatory subunit-associated protein 3; CDK5 activator-binding protein C53; Protein HSF-27
 Product Gene Name   

CDK5RAP3 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608202
 3D Structure    ModBase 3D Structure for Q96JB5
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    CDK5RAP3 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human CDK5RAP3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of CDK5RAP3 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CDK5RAP3 sirna

   siRNA to inhibit CDK5RAP3 expression using RNA interference
 Applications Tested/Suitable for CDK5RAP3 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for CDK5RAP3. It may not necessarily be applicable to this product.
 NCBI GI #    503774379
 NCBI GeneID    80279
 NCBI Accession #    NP_001265126.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278197.1 [Other Products]
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 UniProt Primary Accession #    Q96JB5 [Other Products]
 UniProt Secondary Accession #    Q53FA2; Q9H3F8; Q9H8G0; Q9HBR9; B7Z6N4; D3DTU1; D3DTU2; F5H3I5 [Other Products]
 UniProt Related Accession #    Q96JB5 [Other Products]
 Molecular Weight    59,589 Da
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 NCBI Official Full Name    CDK5 regulatory subunit-associated protein 3 isoform c
 NCBI Official Synonym Full Names    CDK5 regulatory subunit associated protein 3
 NCBI Official Symbol    CDK5RAP3 [Similar Products]
 NCBI Official Synonym Symbols   
C53; IC53; LZAP; HSF-27; MST016; PP1553; OK/SW-cl.114
[Similar Products]
 NCBI Protein Information    CDK5 regulatory subunit-associated protein 3
 UniProt Protein Name    CDK5 regulatory subunit-associated protein 3
 UniProt Synonym Protein Names   
CDK5 activator-binding protein C53; LXXLL/leucine-zipper-containing ARF-binding protein
 Protein Family    CDK5RAP3-like protein
 UniProt Gene Name    CDK5RAP3 [Similar Products]
 UniProt Synonym Gene Names    [Similar Products]
 UniProt Entry Name    CK5P3_HUMAN
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 NCBI Summary for CDK5RAP3    This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
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 UniProt Comments for CDK5RAP3    CDK5RAP3: Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1. Belongs to the CDK5RAP3 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: protein complex; membrane; cytoplasm; nucleolus; endomembrane system; nucleus

Molecular Function: protein binding; cyclin binding; protein kinase binding

Biological Process: cell proliferation; inhibition of NF-kappaB transcription factor; regulation of neuron differentiation; positive regulation of protein ubiquitination; regulation of mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; brain development; regulation of cyclin-dependent protein kinase activity
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 Research Articles on CDK5RAP3    1. C53/LZAP protein bound indirectly to the microtubule (MT), and expression of the C53/LZAP cleavage product caused abnormal MT bundling and NE rupture.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CDK5RAP3 sirnaDiseases associated with CDK5RAP3 sirna
 Reference Product  PubMed Publications
 UFM1 sirna  >2 publications with CDK5RAP3 and UFM1
 PAK4 sirna  >2 publications with CDK5RAP3 and PAK4
 UFL1 sirna  >2 publications with CDK5RAP3 and UFL1
 DDRGK1 sirna  >1 publications with CDK5RAP3 and DDRGK1
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >6 publications with CDK5RAP3 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >6 publications with CDK5RAP3 and Liver Neoplasms
 Intestinal Neoplasms Antibodies  >3 publications with CDK5RAP3 and Intestinal Neoplasms
 Heart Diseases Antibodies  >3 publications with CDK5RAP3 and Heart Diseases
 Cardiovascular Diseases Antibodies  >3 publications with CDK5RAP3 and Cardiovascular Diseases
 Myocardial Ischemia Antibodies  >2 publications with CDK5RAP3 and Myocardial Ischemia
 Atherosclerosis Antibodies  >1 publications with CDK5RAP3 and Atherosclerosis
 Neoplasm Metastasis Antibodies  >1 publications with CDK5RAP3 and Neoplasm Metastasis
 Liver Neoplasms, Experimental Antibodies  >1 publications with CDK5RAP3 and Liver Neoplasms, Experimental
 Necrosis Antibodies  >1 publications with CDK5RAP3 and Necrosis
Organs/Tissues associated with CDK5RAP3 sirna
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >30 publications with CDK5RAP3 and Nerve
 Liver Antibodies  >6 publications with CDK5RAP3 and Liver
 Brain Antibodies  >5 publications with CDK5RAP3 and Brain
 Heart Antibodies  >3 publications with CDK5RAP3 and Heart
 Blood Antibodies  >3 publications with CDK5RAP3 and Blood
 Embryonic Tissue Antibodies  >3 publications with CDK5RAP3 and Embryonic Tissue
 Muscle Antibodies  >3 publications with CDK5RAP3 and Muscle
 Pancreas Antibodies  >2 publications with CDK5RAP3 and Pancreas
 Lung Antibodies  >2 publications with CDK5RAP3 and Lung
 Kidney Antibodies  >2 publications with CDK5RAP3 and Kidney
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