NP_001264078.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
331,195 Da
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 7
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 7
NCBI Official Synonym Symbols
Dz; Mt; Cyn; Edy; Flo; Lda; Obt; Whi; Cycn; Todo; WBE1; metis; GENA 47; GENA 60; Gena 52; A730019I05Rik [Similar Products]
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 7
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 7
UniProt Synonym Protein Names
ATP-dependent helicase CHD7
UniProt Synonym Gene Names
UniProt Entry Name
CHD7_MOUSE
NCBI Summary for CHD7
This gene encodes a protein containing two chromodomains and an ATP-binding helicase domain that functions as a regulator of transcription. Mutations in this gene result in an array of development defects, including inner ear problems. The related gene in humans has been implicated in CHARGE syndrome. [provided by RefSeq, Mar 2013]
UniProt Comments for CHD7
CHD-7: Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and adult tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; EC 3.6.4.12; Nucleolus; Helicase
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; hydrolase activity, acting on acid anhydrides; DNA binding; hydrolase activity; nucleotide binding; chromatin binding; helicase activity; ATP binding
Biological Process: heart morphogenesis; limb development; central nervous system development; olfactory behavior; blood circulation; locomotory behavior; palate development; ear morphogenesis; positive regulation of multicellular organism growth; female genitalia development; adult walking behavior; embryonic hindlimb morphogenesis; regulation of growth hormone secretion; olfactory nerve development; sensory perception of sound; regulation of neurogenesis; regulation of transcription, DNA-dependent; skeletal development; T cell differentiation; adult heart development; blood vessel development; inner ear morphogenesis; camera-type eye development; transcription, DNA-dependent; in utero embryonic development; olfactory bulb development; semicircular canal morphogenesis; cranial nerve development; chromatin modification; genitalia development; retina development in camera-type eye; artery morphogenesis; cognition; nose development; rRNA processing
Research Articles on CHD7
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Products associated with CHD7 sirna
Diseases associated with CHD7 sirna
Organs/Tissues associated with CHD7 sirna
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