NP_057890.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
61,088 Da
NCBI Official Full Name
serine/threonine-protein kinase Chk2
NCBI Official Synonym Full Names
checkpoint kinase 2
NCBI Protein Information
serine/threonine-protein kinase Chk2
UniProt Protein Name
Serine/threonine-protein kinase Chk2
UniProt Synonym Protein Names
CHK2 checkpoint homolog; Checkpoint kinase 2
UniProt Synonym Gene Names
UniProt Entry Name
CHK2_MOUSE
UniProt Comments for CHEK2
Chk2: a CAMK protein kinase of the Rad53 family. A cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. Phosphorylates and inhibits CDC25C, preventing entry into mitosis, p53, leading to cell cycle arrest in G1, and BRCA1, restoring survival after DNA damage. Twelve splice variant isoforms have been described for human Chk2. LOF mutants cause Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype also caused by p53 mutations. Familial mutations also associated with prostate and breast cancer, and mutations also seen in a variety of sporadic cancers and cell lines.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; EC 2.7.11.1; Tumor suppressor; CAMK group; RAD53 family
Cellular Component: nucleoplasm; Golgi apparatus; chromosome, telomeric region; PML body; intracellular; nucleus
Molecular Function: transferase activity; protein serine/threonine kinase activity; identical protein binding; protein homodimerization activity; metal ion binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; protein kinase binding; ATP binding; protein kinase activity
Biological Process: mitosis; transcription, DNA-dependent; DNA damage induced protein phosphorylation; protein stabilization; apoptosis; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; DNA damage response, signal transduction; cell cycle; DNA repair; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; DNA damage response, signal transduction resulting in induction of apoptosis; cellular protein catabolic process; cell division; double-strand break repair; DNA damage checkpoint; response to gamma radiation; regulation of protein catabolic process; G2/M transition of mitotic cell cycle; phosphorylation; response to DNA damage stimulus
Research Articles on CHEK2
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Pathways associated with CHEK2 sirna
Diseases associated with CHEK2 sirna
Organs/Tissues associated with CHEK2 sirna
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