NP_056545.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,305 Da
NCBI Official Full Name
neuronal acetylcholine receptor subunit alpha-4
NCBI Official Synonym Full Names
cholinergic receptor, nicotinic, alpha polypeptide 4
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-4
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-4
UniProt Synonym Gene Names
UniProt Entry Name
ACHA4_MOUSE
UniProt Comments for CHRNA4
nAChRA4: a ligand-gated ion channels that binds acetylcholine and mediates fast signal transmission at synapses. After binding acetylcholine, these pentameric receptors undergo an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. An integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; membrane; cell soma; dendrite; integral to membrane; plasma membrane; synapse; cell junction; external side of plasma membrane
Molecular Function: protein binding; protein heterodimerization activity; acetylcholine receptor activity; ion channel activity; drug binding; acetylcholine binding; nicotinic acetylcholine-activated cation-selective channel activity; extracellular ligand-gated ion channel activity
Biological Process: response to nicotine; positive regulation of dopamine secretion; regulation of action potential; B cell activation; protein heterooligomerization; behavioral response to nicotine; locomotory behavior; respiratory gaseous exchange; DNA repair; signal transduction; sensory perception of pain; regulation of dopamine secretion; neurological system process; synaptic transmission, cholinergic; regulation of inhibitory postsynaptic membrane potential; membrane depolarization; regulation of membrane potential; transport; calcium ion transport; response to hypoxia; ion transport; response to oxidative stress; cognition; cation transport
Research Articles on CHRNA4
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Products associated with CHRNA4 sirna
Pathways associated with CHRNA4 sirna
Diseases associated with CHRNA4 sirna
Organs/Tissues associated with CHRNA4 sirna
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