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CLEC1B sirna

Scan QR to view Datasheet Catalog #    MBS8205885 CLEC1B sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CLEC1B, siRNA

 Also Known As   

CLEC1B siRNA (Mouse)

 Product Synonym Names    CLEC2; C-type lectin domain family 1 member B; C-type lectin-like receptor 2; CLEC-2
 Product Gene Name   

CLEC1B sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9JL99
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    CLEC1B siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse CLEC1B gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of CLEC1B sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for CLEC1B sirna

   siRNA to inhibit CLEC1B expression using RNA interference
 Applications Tested/Suitable for CLEC1B sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for CLEC1B. It may not necessarily be applicable to this product.
 NCBI GI #    323714237
 NCBI GeneID    56760
 NCBI Accession #    NP_001191168.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001204239.1 [Other Products]
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 UniProt Primary Accession #    Q9JL99 [Other Products]
 UniProt Secondary Accession #    A0T1G2 [Other Products]
 UniProt Related Accession #    Q9JL99 [Other Products]
 Molecular Weight    22,870 Da
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 NCBI Official Full Name    C-type lectin domain family 1 member B isoform 2
 NCBI Official Synonym Full Names    C-type lectin domain family 1, member b
 NCBI Official Symbol    Clec1b [Similar Products]
 NCBI Official Synonym Symbols   
Clec2; Clec-2; 1810061I13Rik
[Similar Products]
 NCBI Protein Information    C-type lectin domain family 1 member B
 UniProt Protein Name    C-type lectin domain family 1 member B
 UniProt Synonym Protein Names   
C-type lectin-like receptor 2; CLEC-2
 Protein Family    C-type lectin domain family
 UniProt Gene Name    Clec1b [Similar Products]
 UniProt Synonym Gene Names    Clec2; CLEC-2 [Similar Products]
 UniProt Entry Name    CLC1B_MOUSE
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 UniProt Comments for CLEC1B    CLEC1B: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: membrane; integral to plasma membrane; integral to membrane

Molecular Function: transmembrane receptor activity; carbohydrate binding

Biological Process: cell surface receptor linked signal transduction; platelet formation; signal transduction
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 Research Articles on CLEC1B    1. PI3K and Tec family kinases play a crucial role in the regulation of platelet activation and Syk phosphorylation downstream of the CLEC-2 receptor
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CLEC1B sirnaPathways associated with CLEC1B sirna
 Reference Product  PubMed Publications
 Pdpn sirna  >3 publications with CLEC1B and Pdpn
 Products by Pathway  Pathway Diagram
 GPVI-mediated Activation Cascade Pathway antibodies  GPVI-mediated Activation Cascade Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
Diseases associated with CLEC1B sirnaOrgans/Tissues associated with CLEC1B sirna
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >1 publications with CLEC1B and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with CLEC1B and Liver Diseases
 Hypersensitivity Antibodies  >1 publications with CLEC1B and Hypersensitivity
 Fibrosis Antibodies  >1 publications with CLEC1B and Fibrosis
 Lung Diseases Antibodies  >1 publications with CLEC1B and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with CLEC1B and Liver
 Lymph Node Antibodies  >2 publications with CLEC1B and Lymph Node
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