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COG2 sirna

Scan QR to view Datasheet Catalog #    MBS8225308 COG2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

COG2 siRNA (Human)

 Product Synonym Names    LDLC; Conserved oligomeric Golgi complex subunit 2; COG complex subunit 2; Component of oligomeric Golgi complex 2; Low density lipoprotein receptor defect C-complementing protein
 Product Gene Name   

COG2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606974
 3D Structure    ModBase 3D Structure for Q14746
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    COG2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human COG2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of COG2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for COG2 sirna

   siRNA to inhibit COG2 expression using RNA interference
 Applications Tested/Suitable for COG2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for COG2. It may not necessarily be applicable to this product.
 NCBI GI #    223029519
 NCBI GeneID    22796
 NCBI Accession #    NP_001138508.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145036.1 [Other Products]
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 UniProt Primary Accession #    Q14746 [Other Products]
 UniProt Secondary Accession #    Q86U99 [Other Products]
 UniProt Related Accession #    Q14746 [Other Products]
 Molecular Weight    83,136 Da
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 NCBI Official Full Name    conserved oligomeric Golgi complex subunit 2 isoform 2
 NCBI Official Synonym Full Names    component of oligomeric golgi complex 2
 NCBI Official Symbol    COG2 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    conserved oligomeric Golgi complex subunit 2
 UniProt Protein Name    Conserved oligomeric Golgi complex subunit 2
 UniProt Synonym Protein Names   
Component of oligomeric Golgi complex 2; Low density lipoprotein receptor defect C-complementing protein
 Protein Family    Conserved oligomeric Golgi complex
 UniProt Gene Name    COG2 [Similar Products]
 UniProt Synonym Gene Names    LDLC; COG complex subunit 2 [Similar Products]
 UniProt Entry Name    COG2_HUMAN
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 NCBI Summary for COG2    This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
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 UniProt Comments for COG2    COG2: Required for normal Golgi morphology and function. Belongs to the COG2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1q42.2

Cellular Component: Golgi membrane; Golgi stack; Golgi transport complex; cytosol

Molecular Function: protein binding; protein complex binding; protein transporter activity

Biological Process: intracellular protein transport; intra-Golgi vesicle-mediated transport; oligosaccharide biosynthetic process; protein amino acid glycosylation; Golgi organization and biogenesis
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 Research Articles on COG2    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with COG2 sirnaDiseases associated with COG2 sirna
 Reference Product  PubMed Publications
 COG1 sirna  >14 publications with COG2 and COG1
 COG3 sirna  >14 publications with COG2 and COG3
 COG4 sirna  >8 publications with COG2 and COG4
 COG8 sirna  >7 publications with COG2 and COG8
 COG5 sirna  >7 publications with COG2 and COG5
 COG7 sirna  >4 publications with COG2 and COG7
 GOLGA3 sirna  >1 publications with COG2 and GOLGA3
 APOB sirna  >1 publications with COG2 and APOB
 COG6 sirna  >1 publications with COG2 and COG6
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with COG2 and Necrosis
 Kidney Diseases Antibodies  >1 publications with COG2 and Kidney Diseases
Organs/Tissues associated with COG2 sirna
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >3 publications with COG2 and Ovary
 Nerve Antibodies  >1 publications with COG2 and Nerve
 Liver Antibodies  >1 publications with COG2 and Liver
 Blood Antibodies  >1 publications with COG2 and Blood
 Kidney Antibodies  >1 publications with COG2 and Kidney
 Brain Antibodies  >1 publications with COG2 and Brain
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