NP_689729.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,665 Da
NCBI Official Full Name
COMM domain-containing protein 1
NCBI Official Synonym Full Names
copper metabolism (Murr1) domain containing 1
NCBI Protein Information
COMM domain-containing protein 1
UniProt Protein Name
COMM domain-containing protein 1
UniProt Synonym Protein Names
Protein Murr1
UniProt Synonym Gene Names
UniProt Entry Name
COMD1_HUMAN
NCBI Summary for COMMD1
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
UniProt Comments for COMMD1
COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2p15
Cellular Component: nucleoplasm; Cul2-RING ubiquitin ligase complex; recycling endosome; cytoplasmic membrane-bound vesicle; cytoplasm; early endosome; endosome membrane; nucleus
Molecular Function: identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity; phosphatidylinositol-3,4,5-triphosphate binding; copper ion binding; phosphatidylinositol-3,4-bisphosphate binding
Biological Process: Golgi to plasma membrane transport; protein transport; transcription, DNA-dependent; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; regulation of proteasomal ubiquitin-dependent protein catabolic process; plasma membrane to endosome transport; copper ion homeostasis
Research Articles on COMMD1
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Products associated with COMMD1 sirna
Pathways associated with COMMD1 sirna
Diseases associated with COMMD1 sirna
Organs/Tissues associated with COMMD1 sirna
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