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CORIN sirna

Scan QR to view Datasheet Catalog #    MBS8208648 CORIN sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


★Popular Item★
 Also Known As   


 Product Synonym Names    Atrial natriuretic peptide-converting enzyme; Corin; Pro-ANP-converting enzyme
 Product Gene Name   

CORIN sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q80YN4
 Species Reactivity    Rat
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 Specificity    CORIN siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Source    Synthetic
 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat CORIN gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of CORIN sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CORIN sirna

   siRNA to inhibit CORIN expression using RNA interference
 Applications Tested/Suitable for CORIN sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for CORIN. It may not necessarily be applicable to this product.
 NCBI GI #    32563562
 NCBI GeneID    289596
 NCBI Accession #    NP_872279.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_182473.1 [Other Products]
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 UniProt Primary Accession #    Q80YN4 [Other Products]
 UniProt Secondary Accession #    D3ZN44; F1LS60 [Other Products]
 UniProt Related Accession #    Q80YN4 [Other Products]
 Molecular Weight    122,757 Da
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 NCBI Official Full Name    atrial natriuretic peptide-converting enzyme
 NCBI Official Synonym Full Names    corin, serine peptidase
 NCBI Official Symbol    Corin [Similar Products]
 NCBI Protein Information    atrial natriuretic peptide-converting enzyme
 UniProt Protein Name    Atrial natriuretic peptide-converting enzyme
 UniProt Synonym Protein Names   
Corin; Pro-ANP-converting enzyme
 Protein Family    Atrial natriuretic peptide-converting enzyme
 UniProt Gene Name    Corin [Similar Products]
 UniProt Entry Name    CORIN_RAT
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 UniProt Comments for CORIN    Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide.
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 Research Articles on CORIN    1. corin might be involved in the salt retention seen in glomerular diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CORIN sirnaPathways associated with CORIN sirna
 Reference Product  PubMed Publications
 Furin sirna  >9 publications with CORIN and Furin
 Nppa sirna  >5 publications with CORIN and Nppa
 Npr2 sirna  >1 publications with CORIN and Npr2
 Npr1 sirna  >1 publications with CORIN and Npr1
 Products by Pathway  Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
Diseases associated with CORIN sirnaOrgans/Tissues associated with CORIN sirna
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >75 publications with CORIN and Cardiovascular Diseases
 Heart Diseases Antibodies  >66 publications with CORIN and Heart Diseases
 Heart Failure Antibodies  >43 publications with CORIN and Heart Failure
 Hypertension Antibodies  >40 publications with CORIN and Hypertension
 Hypertrophy Antibodies  >24 publications with CORIN and Hypertrophy
 Cardiomegaly Antibodies  >22 publications with CORIN and Cardiomegaly
 Kidney Diseases Antibodies  >12 publications with CORIN and Kidney Diseases
 Carcinoma Antibodies  >9 publications with CORIN and Carcinoma
 Fibrosis Antibodies  >8 publications with CORIN and Fibrosis
 Congenital Abnormalities Antibodies  >6 publications with CORIN and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >92 publications with CORIN and Heart
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