NP_034124.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,537 Da
NCBI Official Full Name
cytochrome P450 1B1
NCBI Official Synonym Full Names
cytochrome P450, family 1, subfamily b, polypeptide 1
NCBI Protein Information
cytochrome P450 1B1
UniProt Protein Name
Cytochrome P450 1B1
UniProt Synonym Protein Names
CYPIB1; Cytochrome P450CMEF; Cytochrome P450EF
UniProt Synonym Gene Names
UniProt Entry Name
CP1B1_MOUSE
UniProt Comments for CYP1B1
CYP1B1: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Defects in CYP1B1 are the cause of primary congenital glaucoma type 3A (GLC3A). GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. Defects in CYP1B1 are a cause of primary open angle glaucoma (POAG). POAG is a complex and genetically heterogeneous ocular disorder characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. In some cases, POAG shows digenic inheritance involving mutations in CYP1B1 and MYOC genes. Defects in CYP1B1 are a cause of Peters anomaly (PAN). Peters anomaly is a congenital defect of the anterior chamber of the eye. Belongs to the cytochrome P450 family.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - tryptophan; EC 1.14.14.1; Oxidoreductase
Cellular Component: membrane; mitochondrion; intracellular membrane-bound organelle; endoplasmic reticulum; nucleus
Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; oxidoreductase activity; monooxygenase activity
Biological Process: benzene and derivative metabolic process; steroid metabolic process; estrogen metabolic process; retinal metabolic process; collagen fibril organization; positive regulation of translation; dibenzo-p-dioxin metabolic process; positive regulation of apoptosis; response to toxin; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell migration; negative regulation of cell proliferation; retinol metabolic process; arachidonic acid metabolic process; angiogenesis; nitric oxide biosynthetic process; cell adhesion; negative regulation of cell migration; negative regulation of cell adhesion mediated by integrin; DNA modification; positive regulation of angiogenesis; inhibition of NF-kappaB transcription factor; xenobiotic metabolic process; toxin metabolic process; blood vessel morphogenesis; aromatic compound metabolic process; endothelial cell migration; membrane lipid catabolic process; induction of apoptosis by oxidative stress
Research Articles on CYP1B1
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Pathways associated with CYP1B1 sirna
Diseases associated with CYP1B1 sirna
Organs/Tissues associated with CYP1B1 sirna
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