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CYP2D9 sirna

Scan QR to view Datasheet Catalog #    MBS8213354 CYP2D9 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

CYP2D9, siRNA

 Also Known As   

CYP2D9 siRNA (Mouse)

 Product Synonym Names    CYP2D-9; Cytochrome P450 2D9; CYPIID9; Cytochrome P450-16-alpha; Cytochrome P450CA; Testosterone 16-alpha hydroxylase
 Product Gene Name   

CYP2D9 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P11714
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    CYP2D9 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse CYP2D9 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of CYP2D9 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for CYP2D9 sirna

   siRNA to inhibit CYP2D9 expression using RNA interference
 Applications Tested/Suitable for CYP2D9 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for CYP2D9. It may not necessarily be applicable to this product.
 NCBI GI #    160948612
 NCBI GeneID    13105
 NCBI Accession #    NP_034136.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_010006.2 [Other Products]
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 UniProt Primary Accession #    P11714 [Other Products]
 UniProt Secondary Accession #    Q64489; Q921V1 [Other Products]
 UniProt Related Accession #    P11714 [Other Products]
 Molecular Weight    56,950 Da
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 NCBI Official Full Name    cytochrome P450 2D9
 NCBI Official Synonym Full Names    cytochrome P450, family 2, subfamily d, polypeptide 9
 NCBI Official Symbol    Cyp2d9 [Similar Products]
 NCBI Official Synonym Symbols   
Cyp2d; P450-2D
[Similar Products]
 NCBI Protein Information    cytochrome P450 2D9
 UniProt Protein Name    Cytochrome P450 2D9
 UniProt Synonym Protein Names   
CYPIID9; Cytochrome P450-16-alpha; Cytochrome P450CA; Testosterone 16-alpha hydroxylase
 Protein Family    Cytochrome
 UniProt Gene Name    Cyp2d9 [Similar Products]
 UniProt Synonym Gene Names    Cyp2d-9 [Similar Products]
 UniProt Entry Name    CP2D9_MOUSE
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 UniProt Comments for CYP2D9    CYP2D9: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Belongs to the cytochrome P450 family.

Protein type: EC 1.14.14.1; Oxidoreductase

Cellular Component: intracellular membrane-bound organelle; membrane; endoplasmic reticulum; cytoplasm

Molecular Function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; iron ion binding; metal ion binding; heme binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; arachidonic acid epoxygenase activity; oxidoreductase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity

Biological Process: xenobiotic metabolic process; exogenous drug catabolic process; arachidonic acid metabolic process
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with CYP2D9 sirnaPathways associated with CYP2D9 sirna
 Reference Product  PubMed Publications
 Cyp7a1 sirna  >4 publications with CYP2D9 and Cyp7a1
 Hsd3b5 sirna  >3 publications with CYP2D9 and Hsd3b5
 Hnf4a sirna  >1 publications with CYP2D9 and Hnf4a
 Cyp4a12a sirna  >1 publications with CYP2D9 and Cyp4a12a
 Hsd3b2 sirna  >1 publications with CYP2D9 and Hsd3b2
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Phase 1 - Functionalization Of Compounds Pathway antibodies  Phase 1 - Functionalization Of Compounds Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Xenobiotics Pathway antibodies  Xenobiotics Pathway Diagram
 Bupropion Degradation Pathway antibodies  Bupropion Degradation Pathway Diagram
 Nicotine Degradation II Pathway antibodies  Nicotine Degradation II Pathway Diagram
Diseases associated with CYP2D9 sirnaOrgans/Tissues associated with CYP2D9 sirna
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >6 publications with CYP2D9 and Inflammation
 Necrosis Antibodies  >6 publications with CYP2D9 and Necrosis
 Liver Diseases Antibodies  >4 publications with CYP2D9 and Liver Diseases
 Fatty Liver Antibodies  >3 publications with CYP2D9 and Fatty Liver
 Liver Neoplasms Antibodies  >3 publications with CYP2D9 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with CYP2D9 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >2 publications with CYP2D9 and Weight Loss
 Weight Gain Antibodies  >2 publications with CYP2D9 and Weight Gain
 Carcinoma Antibodies  >2 publications with CYP2D9 and Carcinoma
 Kidney Diseases Antibodies  >1 publications with CYP2D9 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >31 publications with CYP2D9 and Liver
 Intestine Antibodies  >2 publications with CYP2D9 and Intestine
 Kidney Antibodies  >2 publications with CYP2D9 and Kidney
 Embryonic Tissue Antibodies  >1 publications with CYP2D9 and Embryonic Tissue
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