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DACT2 sirna

Scan QR to view Datasheet Catalog #    MBS8226153 DACT2 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DACT2, siRNA

 Also Known As   

DACT2 siRNA (Human)

 Product Synonym Names    C6orf116; Dapper homolog 2; Dapper antagonist of catenin 2
 Product Gene Name   

DACT2 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608966
 3D Structure    ModBase 3D Structure for Q5SW24
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    DACT2 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human DACT2 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of DACT2 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DACT2 sirna

   siRNA to inhibit DACT2 expression using RNA interference
 Applications Tested/Suitable for DACT2 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for DACT2. It may not necessarily be applicable to this product.
 NCBI GI #    556503368
 NCBI GeneID    168002
 NCBI Accession #    NP_001273279.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001286350.1 [Other Products]
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 UniProt Primary Accession #    Q5SW24 [Other Products]
 UniProt Secondary Accession #    Q2NKJ2; Q569G0; Q8WYW2 [Other Products]
 UniProt Related Accession #    Q5SW24 [Other Products]
 Molecular Weight    29,350 Da
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 NCBI Official Full Name    dapper homolog 2 isoform b
 NCBI Official Synonym Full Names    dishevelled-binding antagonist of beta-catenin 2
 NCBI Official Symbol    DACT2 [Similar Products]
 NCBI Official Synonym Symbols   
DPR2; DAPPER2; C6orf116; bA503C24.7
[Similar Products]
 NCBI Protein Information    dapper homolog 2
 UniProt Protein Name    Dapper homolog 2
 UniProt Synonym Protein Names   
Dapper antagonist of catenin 2
 Protein Family    Dapper
 UniProt Gene Name    DACT2 [Similar Products]
 UniProt Synonym Gene Names    C6orf116 [Similar Products]
 UniProt Entry Name    DACT2_HUMAN
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 UniProt Comments for DACT2    DACT2: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. Belongs to the dapper family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: mitochondrion

Molecular Function: protein kinase C binding; protein kinase A binding; beta-catenin binding; transcription factor binding

Biological Process: skin development; hemopoietic progenitor cell differentiation; negative regulation of cell adhesion
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 Research Articles on DACT2    1. DACT2 acts as a functional tumor suppressor in colon cancer through inhibiting Wnt/beta-catenin signaling. Its methylation at early stages of colon carcinogenesis is an independent prognostic factor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DACT2 sirnaPathways associated with DACT2 sirna
 Reference Product  PubMed Publications
 DACT3 sirna  >3 publications with DACT2 and DACT3
 PITX2 sirna  >2 publications with DACT2 and PITX2
 TMEM88 sirna  >1 publications with DACT2 and TMEM88
 Products by Pathway  Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
Diseases associated with DACT2 sirnaOrgans/Tissues associated with DACT2 sirna
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >4 publications with DACT2 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with DACT2 and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >2 publications with DACT2 and Neoplasm Metastasis
 Liver Diseases Antibodies  >2 publications with DACT2 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with DACT2 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with DACT2 and Kidney Diseases
 Growth Disorders Antibodies  >1 publications with DACT2 and Growth Disorders
 Fibrosis Antibodies  >1 publications with DACT2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >4 publications with DACT2 and Embryonic Tissue
 Eye Antibodies  >1 publications with DACT2 and Eye
 Placenta Antibodies  >1 publications with DACT2 and Placenta
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