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DENND3 sirna

Scan QR to view Datasheet Catalog #    MBS8214485 DENND3 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

DENND3 siRNA (Mouse)

 Product Synonym Names    KIAA0870; DENN domain-containing protein 3
 Product Gene Name   

DENND3 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for A2RT67
 Host    Synthetic
 Species Reactivity    Mouse
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 Specificity    DENND3 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse DENND3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of DENND3 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DENND3 sirna

   siRNA to inhibit DENND3 expression using RNA interference
 Applications Tested/Suitable for DENND3 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for DENND3. It may not necessarily be applicable to this product.
 NCBI GI #    124486710
 NCBI GeneID    105841
 NCBI Accession #    NP_001074535.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001081066.1 [Other Products]
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 UniProt Primary Accession #    A2RT67 [Other Products]
 UniProt Secondary Accession #    Q69ZX2; Q8C6V5; B2RQ75 [Other Products]
 UniProt Related Accession #    A2RT67 [Other Products]
 Molecular Weight    143,888 Da
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 NCBI Official Full Name    DENN domain-containing protein 3
 NCBI Official Synonym Full Names    DENN/MADD domain containing 3
 NCBI Official Symbol    Dennd3 [Similar Products]
 NCBI Official Synonym Symbols   
AI447457; E030003N15Rik
[Similar Products]
 NCBI Protein Information    DENN domain-containing protein 3
 UniProt Protein Name    DENN domain-containing protein 3
 Protein Family    DENN domain-containing protein
 UniProt Gene Name    Dennd3 [Similar Products]
 UniProt Synonym Gene Names    Kiaa0870 [Similar Products]
 UniProt Entry Name    DEND3_MOUSE
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 UniProt Comments for DENND3    DENND3: a guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form. Plays a role in protein transport from recycling endosomes to lysosomes regulating, for example, the degradation of the transferrin receptor. Four isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rab; GEFs

Cellular Component: cell; intracellular

Molecular Function: guanyl-nucleotide exchange factor activity; Rab guanyl-nucleotide exchange factor activity

Biological Process: cellular protein catabolic process; endosome to lysosome transport; positive regulation of GTPase activity
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 Research Articles on DENND3    1. Dennd3 not only functions as a Rab12-GEF but also modulates Akt signaling in mouse embryonic fibroblast cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Organs/Tissues associated with DENND3 sirna
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >1 publications with DENND3 and Embryonic Tissue
 Spleen Antibodies  >1 publications with DENND3 and Spleen
 Uncharacterized Tissue Antibodies  >1 publications with DENND3 and Uncharacterized Tissue
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