NP_083048.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
97,255 Da
NCBI Official Full Name
dimethylglycine dehydrogenase, mitochondrial
NCBI Official Synonym Full Names
dimethylglycine dehydrogenase precursor
NCBI Protein Information
dimethylglycine dehydrogenase, mitochondrial
UniProt Protein Name
Dimethylglycine dehydrogenase, mitochondrial
UniProt Synonym Protein Names
ME2GLYDH
UniProt Entry Name
M2GD_MOUSE
NCBI Summary for DMGDH
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. [provided by RefSeq, Jul 2013]
UniProt Comments for DMGDH
DMGDH: Defects in DMGDH are the cause of DMGDH deficiency (DMGDHD). DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N- dimethylglycine (DMG) in serum and urine. Belongs to the GcvT family.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; EC 1.5.8.4; Mitochondrial
Cellular Component: mitochondrion
Molecular Function: FAD binding; dimethylglycine dehydrogenase activity; oxidoreductase activity; folic acid binding
Biological Process: glycine metabolic process
Research Articles on DMGDH
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Products associated with DMGDH sirna
Pathways associated with DMGDH sirna
Diseases associated with DMGDH sirna
Organs/Tissues associated with DMGDH sirna
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