NP_076331.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
332,912 Da
NCBI Official Full Name
desmoplakin
NCBI Official Synonym Full Names
desmoplakin
NCBI Official Synonym Symbols
DP; rul; AA407887; AA407888; AW109828; 2300002E22Rik; 5730453H04Rik [Similar Products]
NCBI Protein Information
desmoplakin
UniProt Protein Name
Desmoplakin
UniProt Synonym Gene Names
UniProt Entry Name
DESP_MOUSE
UniProt Comments for DSP
Desmoplakin: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Cytoskeletal
Cellular Component: desmosome; cytoskeleton; mitochondrion; membrane; basolateral plasma membrane; cytoplasm; plasma membrane; intermediate filament; cornified envelope; fascia adherens; intercellular junction; nucleus; cell junction
Molecular Function: protein binding, bridging; protein binding; protein kinase C binding; cell adhesion molecule binding; structural molecule activity
Biological Process: skin development; keratinocyte differentiation; cell-cell adhesion; intermediate filament cytoskeleton organization and biogenesis; intermediate filament organization; peptide cross-linking
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Products associated with DSP sirna
Pathways associated with DSP sirna
Diseases associated with DSP sirna
Organs/Tissues associated with DSP sirna
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