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DVL1 sirna

Scan QR to view Datasheet Catalog #    MBS8232004 DVL1 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

DVL1, siRNA

 Also Known As   

DVL1 siRNA (Human)

 Product Synonym Names    Segment polarity protein dishevelled homolog DVL-1; Dishevelled-1; DSH homolog 1
 Product Gene Name   

DVL1 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601365
 3D Structure    ModBase 3D Structure for O14640
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    DVL1 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human DVL1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of DVL1 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for DVL1 sirna

   siRNA to inhibit DVL1 expression using RNA interference
 Applications Tested/Suitable for DVL1 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for DVL1. It may not necessarily be applicable to this product.
 NCBI GI #    32479521
 NCBI GeneID    1855
 NCBI Accession #    NP_004412.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004421.2 [Other Products]
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 UniProt Primary Accession #    O14640 [Other Products]
 UniProt Secondary Accession #    Q5TA33; Q5TA35 [Other Products]
 UniProt Related Accession #    O14640; P54792 [Other Products]
 Molecular Weight    72,881 Da
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 NCBI Official Full Name    segment polarity protein dishevelled homolog DVL-1
 NCBI Official Synonym Full Names    dishevelled segment polarity protein 1
 NCBI Official Symbol    DVL1 [Similar Products]
 NCBI Official Synonym Symbols   
DVL; DRS2; DVL1L1; DVL1P1
[Similar Products]
 NCBI Protein Information    segment polarity protein dishevelled homolog DVL-1
 UniProt Protein Name    Segment polarity protein dishevelled homolog DVL-1
 UniProt Synonym Protein Names   
DSH homolog 1
 Protein Family    Segment polarity protein dishevelled
 UniProt Gene Name    DVL1 [Similar Products]
 UniProt Synonym Gene Names    Dishevelled-1 [Similar Products]
 UniProt Entry Name    DVL1_HUMAN
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 NCBI Summary for DVL1    DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. [provided by RefSeq, Jul 2008]
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 UniProt Comments for DVL1    DVL1: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs to the DSH family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: microtubule; growth cone; cell soma; clathrin-coated vesicle; axon; cytoplasmic membrane-bound vesicle; cytoplasm; dendrite; synapse; cytoplasmic vesicle; cytosol; lateral plasma membrane

Molecular Function: identical protein binding; protein binding; enzyme binding; frizzled binding; Rac GTPase binding; protein kinase binding

Biological Process: neural tube development; transcription from RNA polymerase II promoter; axon guidance; Wnt receptor signaling pathway; prepulse inhibition; convergent extension involved in neural plate elongation; axon extension; Wnt receptor signaling pathway, planar cell polarity pathway; dendrite morphogenesis; heart development; neurotransmitter secretion; positive regulation of transcription, DNA-dependent; regulation of neurotransmitter levels; social behavior; Wnt receptor signaling pathway through beta-catenin; receptor clustering; cytoplasmic microtubule organization and biogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; collateral sprouting; synapse organization and biogenesis; negative regulation of protein kinase activity; negative regulation of protein binding; positive regulation of Wnt receptor signaling pathway; neuromuscular junction development

Disease: Robinow Syndrome, Autosomal Dominant; Robinow Syndrome, Autosomal Dominant 2
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 Research Articles on DVL1    1. Data indicate Dishevelled (DVL) as a dual function adaptor to recruit negative regulators ZNRF3/RNF43 to Wnt receptors to ensure proper control of pathway activity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with DVL1 sirnaPathways associated with DVL1 sirna
 Reference Product  PubMed Publications
 CTNNB1 sirna  >22 publications with DVL1 and CTNNB1
 WNT5A sirna  >9 publications with DVL1 and WNT5A
 WNT3A sirna  >7 publications with DVL1 and WNT3A
 LRP6 sirna  >3 publications with DVL1 and LRP6
 NKD1 sirna  >3 publications with DVL1 and NKD1
 AXIN1 sirna  >3 publications with DVL1 and AXIN1
 DAAM1 sirna  >2 publications with DVL1 and DAAM1
 NKD2 sirna  >2 publications with DVL1 and NKD2
 CSNK1E sirna  >1 publications with DVL1 and CSNK1E
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
Diseases associated with DVL1 sirnaOrgans/Tissues associated with DVL1 sirna
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >10 publications with DVL1 and Breast Neoplasms
 Carcinoma Antibodies  >9 publications with DVL1 and Carcinoma
 Nervous System Diseases Antibodies  >7 publications with DVL1 and Nervous System Diseases
 Lung Neoplasms Antibodies  >6 publications with DVL1 and Lung Neoplasms
 Brain Diseases Antibodies  >4 publications with DVL1 and Brain Diseases
 Adenocarcinoma Antibodies  >4 publications with DVL1 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >3 publications with DVL1 and Neoplasm Metastasis
 Nervous System Malformations Antibodies  >3 publications with DVL1 and Nervous System Malformations
 Prostatic Neoplasms Antibodies  >3 publications with DVL1 and Prostatic Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with DVL1 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with DVL1 and Brain
 Embryonic Tissue Antibodies  >12 publications with DVL1 and Embryonic Tissue
 Nerve Antibodies  >9 publications with DVL1 and Nerve
 Lung Antibodies  >9 publications with DVL1 and Lung
 Muscle Antibodies  >7 publications with DVL1 and Muscle
 Bone Antibodies  >6 publications with DVL1 and Bone
 Prostate Antibodies  >4 publications with DVL1 and Prostate
 Heart Antibodies  >4 publications with DVL1 and Heart
 Adipose Tissue Antibodies  >3 publications with DVL1 and Adipose Tissue
 Kidney Antibodies  >2 publications with DVL1 and Kidney
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