NP_034240.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
37,859 Da
NCBI Official Full Name
ephrin-B1
NCBI Official Synonym Full Names
ephrin B1
NCBI Official Synonym Symbols
Epl2; EFL-3; Elk-L; Eplg2; Lerk2; Stra1; Cek5-L; LERK-2 [Similar Products]
NCBI Protein Information
ephrin-B1
UniProt Protein Name
Ephrin-B1
UniProt Synonym Protein Names
CEK5 receptor ligand; CEK5-L; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; Stimulated by retinoic acid gene 1 protein
UniProt Synonym Gene Names
UniProt Entry Name
EFNB1_MOUSE
NCBI Summary for EFNB1
This gene encodes a membrane protein that acts as a ligand for Eph family receptors. Signalling occurs bidirectionally in both the cell containing the receptor and the cell expressing this protein. Activity of this protein is important in neuronal axon growth and other developmental processes. [provided by RefSeq, May 2015]
UniProt Comments for EFNB1
EFNB1: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphB1 and EphA1. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B1 may play a role in cell adhesion and functions in the development or maintenance of the nervous system. Binding to its receptor induces the collapse of commissural axons/growth cones in vitro. Induced by TNF-alpha. Expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral
Cellular Component: membrane; cytoplasm; integral to membrane; plasma membrane; synapse; nucleus; lipid raft
Molecular Function: protein binding; ephrin receptor binding
Biological Process: axon guidance; nervous system development; multicellular organismal development; ephrin receptor signaling pathway; positive regulation of T cell proliferation; cell differentiation; embryonic pattern specification; neural crest cell migration
Research Articles on EFNB1
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Pathways associated with EFNB1 sirna
Diseases associated with EFNB1 sirna
Organs/Tissues associated with EFNB1 sirna
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