NP_067719.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
145,376 Da
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-4
NCBI Official Synonym Full Names
erb-b2 receptor tyrosine kinase 4
NCBI Protein Information
receptor tyrosine-protein kinase erbB-4
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-4
UniProt Synonym Protein Names
Proto-oncogene-like protein c-ErbB-4
UniProt Synonym Gene Names
UniProt Entry Name
ERBB4_RAT
NCBI Summary for ERBB4
binds neuregulins; involved in epithelial-mesenchymal interactions during development; may play a role in tooth morphogenesis [RGD, Feb 2006]
UniProt Comments for ERBB4
HER4: a receptor tyrosine kinase of the EGFR family. Specifically binds and is activated by neuregulins, NRG- 2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Heterodimerizes and signals with other EGF receptors. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX. May act as a tumor suppressor: overexpressed in head and neck cancer , but downregulated in renal cancer, papillary carcinoma, high-grade gliomas and invasive breast cancer. 3 alternatively-spliced isoforms of the human protein have been reported.
Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; TK group; EGFR family
Cellular Component: mitochondrion; basolateral plasma membrane; cytoplasm; postsynaptic density; integral to membrane; plasma membrane; caveola; nucleus; receptor complex; lipid raft
Molecular Function: protein binding; protein homodimerization activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; epidermal growth factor receptor binding
Biological Process: lactation; synapse maturation; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; heart development; signal transduction; embryonic pattern specification; olfactory bulb interneuron differentiation; regulation of cell migration; odontogenesis; negative regulation of cell proliferation; positive regulation of glucose import; mammary gland development; positive regulation of cell proliferation; neural crest cell migration; positive regulation of cardiac muscle cell proliferation; response to drug; nervous system development; cell migration; cell fate commitment; transcription, DNA-dependent; positive regulation of synaptic transmission, GABAergic; positive regulation of phosphoinositide 3-kinase activity; telencephalon development; central nervous system morphogenesis; response to hydrogen peroxide; positive regulation of tyrosine phosphorylation of Stat5 protein; mitochondrial fragmentation during apoptosis; response to progesterone stimulus; surfactant homeostasis; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on ERBB4
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Products associated with ERBB4 sirna
Pathways associated with ERBB4 sirna
Diseases associated with ERBB4 sirna
Organs/Tissues associated with ERBB4 sirna
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