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EXOC4 sirna

Scan QR to view Datasheet Catalog #    MBS8206010 EXOC4 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

EXOC4 siRNA (Human)

 Product Synonym Names    KIAA1699; SEC8; SEC8L1; Exocyst complex component 4; Exocyst complex component Sec8
 Product Gene Name   

EXOC4 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608185
 3D Structure    ModBase 3D Structure for Q96A65
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    EXOC4 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human EXOC4 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of EXOC4 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for EXOC4 sirna

   siRNA to inhibit EXOC4 expression using RNA interference
 Applications Tested/Suitable for EXOC4 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for EXOC4. It may not necessarily be applicable to this product.
 NCBI GI #    82546830
 NCBI GeneID    60412
 NCBI Accession #    NP_068579.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_021807.3 [Other Products]
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 UniProt Primary Accession #    Q96A65 [Other Products]
 UniProt Secondary Accession #    Q541U8; Q9C0G4; Q9H9K0; Q9P102; E9PED2 [Other Products]
 UniProt Related Accession #    Q96A65 [Other Products]
 Molecular Weight    53,857 Da
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 NCBI Official Full Name    exocyst complex component 4 isoform a
 NCBI Official Synonym Full Names    exocyst complex component 4
 NCBI Official Symbol    EXOC4 [Similar Products]
 NCBI Official Synonym Symbols   
SEC8; Sec8p; SEC8L1
[Similar Products]
 NCBI Protein Information    exocyst complex component 4
 UniProt Protein Name    Exocyst complex component 4
 UniProt Synonym Protein Names   
Exocyst complex component Sec8
 UniProt Gene Name    EXOC4 [Similar Products]
 UniProt Synonym Gene Names    KIAA1699; SEC8; SEC8L1 [Similar Products]
 UniProt Entry Name    EXOC4_HUMAN
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 NCBI Summary for EXOC4    The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for EXOC4    EXOC4: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC8 family.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: membrane; cytoplasm; exocyst; plasma membrane; cytosol

Molecular Function: protein binding; Ral GTPase binding; protein N-terminus binding; PDZ domain binding

Biological Process: protein transport; cellular protein metabolic process; organelle organization and biogenesis; vesicle docking during exocytosis
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 Research Articles on EXOC4    1. knockdown of Sec8 enhances the binding of JIP4 to MAPK kinase 4, thereby decreasing the phosphorylation of MAPK kinase 4, JNK, and p38.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with EXOC4 sirnaPathways associated with EXOC4 sirna
 Reference Product  PubMed Publications
 EXOC3 sirna  >12 publications with EXOC4 and EXOC3
 EXOC7 sirna  >4 publications with EXOC4 and EXOC7
 EXOC2 sirna  >2 publications with EXOC4 and EXOC2
 EXOC8 sirna  >2 publications with EXOC4 and EXOC8
 EXOC6 sirna  >1 publications with EXOC4 and EXOC6
 EXOC1 sirna  >1 publications with EXOC4 and EXOC1
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Processing Pathway antibodies  Insulin Processing Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway antibodies  Stabilization And Expansion Of The E-cadherin Adherens Junction Pathway Diagram
Diseases associated with EXOC4 sirnaOrgans/Tissues associated with EXOC4 sirna
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with EXOC4 and Carcinoma
 Chromosome Aberrations Antibodies  >2 publications with EXOC4 and Chromosome Aberrations
 Kidney Diseases Antibodies  >2 publications with EXOC4 and Kidney Diseases
 Immune System Diseases Antibodies  >1 publications with EXOC4 and Immune System Diseases
 Breast Neoplasms Antibodies  >1 publications with EXOC4 and Breast Neoplasms
 Carcinoma, Squamous Cell Antibodies  >1 publications with EXOC4 and Carcinoma, Squamous Cell
 Urinary Bladder Neoplasms Antibodies  >1 publications with EXOC4 and Urinary Bladder Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with EXOC4 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >1 publications with EXOC4 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >1 publications with EXOC4 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with EXOC4 and Brain
 Nerve Antibodies  >5 publications with EXOC4 and Nerve
 Kidney Antibodies  >3 publications with EXOC4 and Kidney
 Muscle Antibodies  >3 publications with EXOC4 and Muscle
 Blood Antibodies  >3 publications with EXOC4 and Blood
 Mouth Antibodies  >1 publications with EXOC4 and Mouth
 Liver Antibodies  >1 publications with EXOC4 and Liver
 Lung Antibodies  >1 publications with EXOC4 and Lung
 Embryonic Tissue Antibodies  >1 publications with EXOC4 and Embryonic Tissue
 Bone Antibodies  >1 publications with EXOC4 and Bone
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