NP_032081.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
60,143 Da
NCBI Official Full Name
frizzled-4
NCBI Official Synonym Full Names
frizzled homolog 4 (Drosophila)
NCBI Official Synonym Symbols
NCBI Protein Information
frizzled-4
UniProt Protein Name
Frizzled-4
UniProt Synonym Protein Names
CD_antigen: CD344
UniProt Synonym Gene Names
UniProt Entry Name
FZD4_MOUSE
UniProt Comments for FZD4
FZD4: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Defects in FZD4 are the cause of vitreoretinopathy exudative type 1 (EVR1); also known as autosomal dominant familial exudative vitreoretinopathy (FEVR) or Criswick- Schepens syndrome. EVR1 is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery. Belongs to the G-protein coupled receptor Fz/Smo family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, Fz/Smo family
Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; intercellular junction
Molecular Function: G-protein coupled receptor activity; Wnt-protein binding; protein binding; Wnt receptor activity; signal transducer activity; transmembrane receptor activity; protein homodimerization activity; protein heterodimerization activity; ubiquitin protein ligase binding; cytokine binding; PDZ domain binding
Biological Process: positive regulation of JNK activity; blood vessel development; Wnt receptor signaling pathway; multicellular organismal development; positive regulation of transcription, DNA-dependent; Wnt receptor signaling pathway through beta-catenin; signal transduction; progesterone secretion; locomotion during locomotory behavior; G-protein coupled receptor protein signaling pathway; Wnt receptor signaling pathway, calcium modulating pathway; cell surface receptor linked signal transduction; sensory perception of sound; regulation of vascular endothelial growth factor receptor signaling pathway; luteinization; positive regulation of transcription factor activity; vasculogenesis
Research Articles on FZD4
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Products associated with FZD4 sirna
Pathways associated with FZD4 sirna
Diseases associated with FZD4 sirna
Organs/Tissues associated with FZD4 sirna
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