NP_444504.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,166 Da
NCBI Official Full Name
glomulin
NCBI Official Synonym Full Names
glomulin, FKBP associated protein
NCBI Official Synonym Symbols
FAP; GVM; GLML; FAP48; FAP68; FKBPAP; VMGLOM [Similar Products]
NCBI Protein Information
glomulin
UniProt Protein Name
Glomulin
UniProt Synonym Protein Names
FK506-binding protein-associated protein; FAP; FKBP-associated protein
UniProt Synonym Gene Names
UniProt Entry Name
GLMN_HUMAN
NCBI Summary for GLMN
This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for GLMN
GLMN: Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Isoform 1 may stimulate the p70S6K pathway. Isoform 2 may inhibit cell proliferation and increase IL2 production. Defects in GLMN are the cause of glomuvenous malformations (GVMs). GVMs are characterized by the presence of smooth-muscle-like glomus cells in the media surrounding distended vascular lumens. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component: Cul2-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex; intracellular
Molecular Function: protein binding; hepatocyte growth factor receptor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase inhibitor activity
Biological Process: muscle cell differentiation; negative regulation of T cell proliferation; positive regulation of interleukin-2 biosynthetic process; neural tube closure; regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein ubiquitination; vasculogenesis; regulation of gene expression, epigenetic; positive regulation of phosphorylation; positive regulation of cytokine secretion
Disease: Glomuvenous Malformations
Research Articles on GLMN
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Products associated with GLMN sirna
Diseases associated with GLMN sirna
Organs/Tissues associated with GLMN sirna
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