NP_062664.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
121,505 Da
NCBI Official Full Name
protein SCG6 (secretogranin VI) isoform SCG6
NCBI Official Synonym Full Names
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus
NCBI Official Synonym Symbols
P1; P2; P3; GSP; Gsa; POH; GPSA; Nesp; SCG6; Gnas1; Nespl; PHP1A; PHP1B; Gnasxl; Nesp55; Oedsml; Galphas; Oed-Sml; Gs-alpha; 5530400H20Rik; A930027G11Rik; C130027O20Rik [Similar Products]
NCBI Protein Information
protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
UniProt Protein Name
Neuroendocrine secretory protein 55
UniProt Synonym Gene Names
UniProt Entry Name
GNAS3_MOUSE
NCBI Summary for GNAS
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]
UniProt Comments for GNAS
G-alpha(s) iso8: a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein type: G protein; Membrane protein, peripheral; Oncoprotein; Vesicle; G protein, heterotrimeric; G protein, heterotrimeric alpha G(s)
Cellular Component: dendrite; extracellular region; cytosol; lipid raft; ruffle; cell projection; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; heterotrimeric G-protein complex; trans-Golgi network membrane; intrinsic to membrane; cytoplasmic vesicle; nucleus; vesicle; endosome; sarcolemma
Molecular Function: GTPase activity; corticotropin-releasing hormone receptor 1 binding; protein domain specific binding; GTP binding; guanyl nucleotide binding; metal ion binding; nucleotide binding; G-protein alpha-subunit binding; G-protein beta-subunit binding; ionotropic glutamate receptor binding; insulin-like growth factor receptor binding; signal transducer activity; protein binding; mu-type opioid receptor binding; G-protein beta/gamma-subunit binding; beta-2 adrenergic receptor binding; D1 dopamine receptor binding; alpha-tubulin binding
Biological Process: skin development; developmental growth; positive regulation of osteoclast differentiation; signal transduction; G-protein signaling, adenylate cyclase activating pathway; embryonic hindlimb morphogenesis; post-embryonic development; calcium ion homeostasis; positive regulation of cAMP biosynthetic process; tissue homeostasis; DNA methylation; negative regulation of blood pressure; skeletal development; post-embryonic body morphogenesis; dopamine receptor, adenylate cyclase activating pathway; endochondral ossification; response to drug; sensory perception of chemical stimulus; negative regulation of multicellular organism growth; multicellular organism growth; embryonic cranial skeleton morphogenesis; regulation of transcription from RNA polymerase II promoter; G-protein coupled receptor protein signaling pathway; positive regulation of osteoblast differentiation; cartilage development; energy reserve metabolic process; positive regulation of protein amino acid phosphorylation; cognition
Research Articles on GNAS
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Pathways associated with GNAS sirna
Diseases associated with GNAS sirna
Organs/Tissues associated with GNAS sirna
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