NP_570090.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,077 Da
NCBI Official Full Name
guanine nucleotide-binding protein subunit beta-2-like 1
NCBI Official Synonym Full Names
guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1
NCBI Official Synonym Symbols
NCBI Protein Information
guanine nucleotide-binding protein subunit beta-2-like 1
UniProt Protein Name
Guanine nucleotide-binding protein subunit beta-2-like 1
UniProt Synonym Protein Names
Receptor for activated C kinase; Receptor of activated protein kinase C 1; RACK1
UniProt Synonym Gene Names
UniProt Entry Name
GBLP_RAT
NCBI Summary for GNB2L1
may act as a receptor for activated protein kinase C [RGD, Feb 2006]
UniProt Comments for GNB2L1
RACK1: a G-beta like protein containing 7 WD domains. A presumptive scaffold protein, linking protein kinase C to its substrates. Binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. An insulin-like growth factor 1 receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.
Protein type: G protein, heterotrimeric; G protein, heterotrimeric beta; Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Adaptor/scaffold; G protein
Cellular Component: small ribosomal subunit; mitochondrion; dendrite; perikaryon; cytosol; cytoskeleton; membrane; cell soma; perinuclear region of cytoplasm; cytoplasm; midbody; nucleus; phagocytic cup
Molecular Function: protein tyrosine kinase inhibitor activity; enzyme binding; protein homodimerization activity; protein kinase C binding; caspase activator activity; SH2 domain binding; receptor tyrosine kinase binding; protein phosphatase binding; ion channel inhibitor activity
Biological Process: caspase activation; negative regulation of phagocytosis; negative regulation of Wnt receptor signaling pathway; negative regulation of protein kinase B signaling cascade; positive regulation of protein homooligomerization; positive regulation of apoptosis; regulation of cell cycle; rhythmic process; gastrulation; osteoblast differentiation; regulation of protein localization; positive regulation of mitochondrial depolarization; negative regulation of translation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein kinase C activation; positive regulation of cAMP catabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of protein amino acid phosphorylation; negative regulation of cell growth; regulation of cell division; positive regulation of cell migration; positive regulation of GTPase activity
Research Articles on GNB2L1
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Products associated with GNB2L1 sirna
Pathways associated with GNB2L1 sirna
Diseases associated with GNB2L1 sirna
Organs/Tissues associated with GNB2L1 sirna
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