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GPR17 sirna

Scan QR to view Datasheet Catalog #    MBS8238967 GPR17 sirna
Unit / Price
15 nmol  /  $365 +1 FREE 8GB USB
30 nmol  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPR17, siRNA

 Also Known As   

GPR17 siRNA (Human)

 Product Synonym Names    Uracil nucleotide/cysteinyl leukotriene receptor; UDP/CysLT receptor; G-protein coupled receptor 17; P2Y-like receptor; R12
 Product Gene Name   

GPR17 sirna

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603071
 3D Structure    ModBase 3D Structure for Q13304
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 Host    Synthetic
 Species Reactivity    Human
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 Specificity    GPR17 siRNA (Human) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
 Purity/Purification    > 97%
 Form/Format    Lyophilized powder
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 Quality Control    Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
 Directions for Use    We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
 Components    We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of human GPR17 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
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 Preparation and Storage    Shipped at 4 degree C. Store at -20 degree C for one year.
 Negative Control    siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
 Other Notes    Small volumes of GPR17 sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GPR17 sirna

   siRNA to inhibit GPR17 expression using RNA interference
 Applications Tested/Suitable for GPR17 sirna   

RNA Interference (RNAi)

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NCBI/Uniprot data below describe general gene information for GPR17. It may not necessarily be applicable to this product.
 NCBI GI #    238814302
 NCBI GeneID    2840
 NCBI Accession #    NP_001154887.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001161415.1 [Other Products]
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 UniProt Primary Accession #    Q13304 [Other Products]
 UniProt Secondary Accession #    Q8N5S7; Q9UDZ6; Q9UE21; A8K9L0; B2R9X0 [Other Products]
 UniProt Related Accession #    Q13304 [Other Products]
 Molecular Weight    37,827 Da
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 NCBI Official Full Name    uracil nucleotide/cysteinyl leukotriene receptor isoform a
 NCBI Official Synonym Full Names    G protein-coupled receptor 17
 NCBI Official Symbol    GPR17 [Similar Products]
 NCBI Protein Information    uracil nucleotide/cysteinyl leukotriene receptor
 UniProt Protein Name    Uracil nucleotide/cysteinyl leukotriene receptor
 UniProt Synonym Protein Names   
G-protein coupled receptor 17; P2Y-like receptor; R12
 Protein Family    Uracil nucleotide/cysteinyl leukotriene receptor
 UniProt Gene Name    GPR17 [Similar Products]
 UniProt Synonym Gene Names    UDP/CysLT receptor [Similar Products]
 UniProt Entry Name    GPR17_HUMAN
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 UniProt Comments for GPR17    GPR17: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q21

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway
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 Research Articles on GPR17    1. GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GPR17 sirnaPathways associated with GPR17 sirna
 Reference Product  PubMed Publications
 CYSLTR1 sirna  >2 publications with GPR17 and CYSLTR1
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Eicosanoid Ligand-binding Receptors Pathway antibodies  Eicosanoid Ligand-binding Receptors Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Leukotriene Receptors Pathway antibodies  Leukotriene Receptors Pathway Diagram
Diseases associated with GPR17 sirnaOrgans/Tissues associated with GPR17 sirna
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with GPR17 and Inflammation
 Immune System Diseases Antibodies  >4 publications with GPR17 and Immune System Diseases
 Asthma Antibodies  >2 publications with GPR17 and Asthma
 Chromosome Aberrations Antibodies  >1 publications with GPR17 and Chromosome Aberrations
 Fibrosis Antibodies  >1 publications with GPR17 and Fibrosis
 Edema Antibodies  >1 publications with GPR17 and Edema
 Learning Disorders Antibodies  >1 publications with GPR17 and Learning Disorders
 Necrosis Antibodies  >1 publications with GPR17 and Necrosis
 Brain Infarction Antibodies  >1 publications with GPR17 and Brain Infarction
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >32 publications with GPR17 and Brain
 Heart Antibodies  >6 publications with GPR17 and Heart
 Kidney Antibodies  >5 publications with GPR17 and Kidney
 Muscle Antibodies  >4 publications with GPR17 and Muscle
 Lung Antibodies  >3 publications with GPR17 and Lung
 Placenta Antibodies  >2 publications with GPR17 and Placenta
 Uncharacterized Tissue Antibodies  >1 publications with GPR17 and Uncharacterized Tissue
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